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Poloxamer-188 and citicoline provide neuronal membrane integrity and protect membrane stability in cortical spreading depression

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dc.contributor.author Dalkara, Turgay
dc.contributor.author Erdener, Sefik Evren
dc.contributor.author Eylen, Alpaslan
dc.contributor.author Gursoy-Ozdemir, Yasemin
dc.contributor.author Karatas, Hulya
dc.contributor.author Lule, Sevda
dc.contributor.author Ozveren, Mehmet Faik
dc.contributor.author Vural, Atay
dc.contributor.author Yildirim, Timur
dc.date.accessioned 2022-08-17T07:03:56Z
dc.date.available 2022-08-17T07:03:56Z
dc.date.issued 2015
dc.identifier.uri http://doi.org/10.3109/00207454.2014.979289
dc.identifier.uri http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2671
dc.description.abstract Under pathological conditions such as brain trauma, subarachnoid hemorrhage and stroke, cortical spreading depression (CSD) or peri-infarct depolarizations contribute to brain damage in animal models of neurological disorders as well as in human neurological diseases. CSD causes transient megachannel opening on the neuronal membrane, which may compromise neuronal survival under pathological conditions. Poloxamer-188 (P-188) and citicoline are neuroprotectants with membrane sealing properties. The aim of this study is to investigate the effect of P-188 and citicoline on the neuronal megachannel opening induced by CSD in the mouse brain. We have monitored megachannel opening with propidium iodide, a membrane impermeable fluorescent dye and, demonstrate that P-188 and citicoline strikingly decreased CSD-induced neuronal PI influx in cortex and hippocampal dentate gyrus. Therefore, these agents may be providing neuroprotection by blocking megachannel opening, which may be related to their membrane sealing action and warrant further investigation for treatment of traumatic brain injury and ischemic stroke. en_US
dc.language.iso eng en_US
dc.publisher TAYLOR & FRANCIS LTD2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND en_US
dc.relation.isversionof 10.3109/00207454.2014.979289 en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject cortical spreading depressionmegachannelsneuroprotectionpoloxamer-188citicoline en_US
dc.subject TRANSIENT FOREBRAIN ISCHEMIATRAUMATIC BRAIN-INJURYCDP-CHOLINECLINICAL-RELEVANCEMECHANISMSNEUROPROTECTIONMIGRAINEDAMAGERATDEPOLARIZATION en_US
dc.title Poloxamer-188 and citicoline provide neuronal membrane integrity and protect membrane stability in cortical spreading depression en_US
dc.type article en_US
dc.relation.journal INTERNATIONAL JOURNAL OF NEUROSCIENCE en_US
dc.contributor.department Ordu Üniversitesi en_US
dc.contributor.authorID 0000-0001-7066-6471 en_US
dc.contributor.authorID 0000-0002-0860-8964 en_US
dc.contributor.authorID 0000-0003-3222-874X en_US
dc.contributor.authorID 0000-0003-3943-7819 en_US
dc.contributor.authorID 0000-0003-4838-6320 en_US
dc.identifier.volume 125 en_US
dc.identifier.issue 12 en_US
dc.identifier.startpage 941 en_US
dc.identifier.endpage 946 en_US


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