DSpace Repository

Effects of Boric Acid on Fracture Healing: An Experimental Study

Show simple item record

dc.contributor.author Arpaci, Rabia
dc.contributor.author Cevizci, Sibel
dc.contributor.author Goksel, Ferdi
dc.contributor.author Golge, Umut Hatay
dc.contributor.author Guven, Mustafa
dc.contributor.author Guzel, Yunus
dc.contributor.author Kaymaz, Burak
dc.contributor.author Komurcu, Erkam
dc.date.accessioned 2022-08-17T07:02:39Z
dc.date.available 2022-08-17T07:02:39Z
dc.date.issued 2015
dc.identifier.uri http://doi.org/10.1007/s12011-015-0326-3
dc.identifier.uri http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2662
dc.description.abstract Boric acid (BA) has positive effects on bone tissue. In this study, the effects of BA on fracture healing were evaluated in an animal model. Standard closed femoral shaft fractures were created in 40 male Sprague-Dawley rats under general anesthesia. The rats were allocated into five groups (n= 8 each): group 1, control with no BA; groups 2 and 3, oral BA at doses of 4 and 8 mg/kg/day, respectively; group 4, local BA (8 mg/kg); and group 5, both oral and local BA (8 mg/kg/day orally and 8 mg/kg locally). After closed fracture creation, the fracture line was opened with a mini-incision, and BA was locally administered to the fracture area in groups 4 and 5. In groups 2, 3, and 5, BA was administered by gastric gavage daily until sacrifice. The rats were evaluated by clinical, radiological, and histological examinations. The control group (group 1) significantly differed from the local BA-exposed groups (groups 4 and 5) in the clinical evaluation. Front-rear and lateral radiographs revealed significant differences between the local BA-exposed groups and the control and other groups (p< 0.05). Clinical and radiological evaluations demonstrated adequate agreement between observers. The average histological scores significantly differed across groups (p= 0.007) and were significantly higher in groups 4 and 5 which were the local BA (8 mg/kg) and both oral and local BA (8 mg/kg/day orally and 8 mg/kg locally), respectively, compared to the controls. This study suggests that BA may be useful in fracture healing. Further research is required to demonstrate the most effective local dosage and possible use of BA-coated implants. en_US
dc.language.iso eng en_US
dc.publisher HUMANA PRESS INC999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 en_US
dc.relation.isversionof 10.1007/s12011-015-0326-3 en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Boric acidFracture healingRatsFemur en_US
dc.subject DIETARY BORONRATSPARAMETERSMETABOLISMSUPPLEMENTATIONENHANCEMENTMAGNESIUMCALCIUMGROWTH en_US
dc.title Effects of Boric Acid on Fracture Healing: An Experimental Study en_US
dc.type article en_US
dc.relation.journal BIOLOGICAL TRACE ELEMENT RESEARCH en_US
dc.contributor.department Ordu Üniversitesi en_US
dc.contributor.authorID 0000-0001-8643-9775 en_US
dc.contributor.authorID 0000-0002-8555-0460 en_US
dc.identifier.volume 167 en_US
dc.identifier.issue 2 en_US
dc.identifier.startpage 264 en_US
dc.identifier.endpage 271 en_US


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account