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Comparison of Dexmedetomidine Versus Ketamine-Propofol Combination for Sedation in Cataract Surgery

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dc.contributor.author Karakahya, Refika Hande
dc.contributor.author Kucuk, Ahmet
dc.contributor.author Tas, Nilay
dc.contributor.author Yagan, Ozgur
dc.date.accessioned 2022-08-17T07:00:43Z
dc.date.available 2022-08-17T07:00:43Z
dc.date.issued 2015
dc.identifier.uri http://doi.org/10.5152/TJAR.2014.45220
dc.identifier.uri http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2652
dc.description.abstract Objective: The aim of this study is to compare the sedative properties and haemodynamic and respiratory effects of dexmedetomidine and a ketamine-propofol combination (ketofol), which are expected to have minimal effects on spontaneous breathing. Methods: Sixty patients were enrolled in this prospective randomised study. Patients were divided into 2 groups according to the administration of dexmedetomidine (Group D) and ketofol (Group K). Target sedation level was determined as a Ramsay Sedation Score of 3. In Group D, 0.5 mcg kg(-1) dexmedetomidine was administered via intravenous route in 10 minutes versus 0.125 mL kg(-1) of a solution containing 200 mg propofol and 100 mg ketamine in Group K. Haemodynamic and respiratory effects, postoperative awakening time, analgesic properties and satisfaction levels of the patients and surgeon were assessed. Results: There was a statistically significant decrease in mean arterial pressures following drug administration compared to initial measurements in both groups. However, there was a statistically significant decrease in heart rate only in Group D. There was no significant difference between the two groups regarding respiratory rate and protection of spontaneous respiration. Although the time for Aldrete score to be 9 was 16.1 minutes for Group K, it was 24.9 minutes for Group D, and this difference was statistically significant (p<0.01). There was no significant difference between the two groups regarding adverse effects, pain scores and satisfaction levels of the patients and surgeon. Conclusion: Compared to dexmedetomidine, at similar sedation levels, sedation provided by ketofol enables satisfactory analgesia. Moreover, ketofol has a more rapid onset of action and a shorter recovery period from anaesthesia without causing significant haemodynamic or respiratory adverse effects. en_US
dc.language.iso eng en_US
dc.publisher AVESBUYUKDERE CAD 105-9, MECIDIYEKOY, SISLI, ISTANBUL 34394, TURKEY en_US
dc.relation.isversionof 10.5152/TJAR.2014.45220 en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Dexmedetomidineketofolsedationcataract surgery en_US
dc.subject MONITORED ANESTHESIA CAREPROCEDURAL SEDATIONBISPECTRAL INDEXINTRAOPERATIVE SEDATIONEMERGENCY-DEPARTMENTPEDIATRIC-PATIENTSANALGESIAINFUSIONMIDAZOLAMFENTANYL en_US
dc.title Comparison of Dexmedetomidine Versus Ketamine-Propofol Combination for Sedation in Cataract Surgery en_US
dc.type article en_US
dc.relation.journal TURKISH JOURNAL OF ANAESTHESIOLOGY AND REANIMATION en_US
dc.contributor.department Ordu Üniversitesi en_US
dc.contributor.authorID 0000-0002-1434-3229 en_US
dc.contributor.authorID 0000-0003-1596-1421 en_US
dc.identifier.volume 43 en_US
dc.identifier.issue 2 en_US
dc.identifier.startpage 84 en_US
dc.identifier.endpage 90 en_US


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