dc.contributor.author |
Canakci, Ebru |
|
dc.contributor.author |
Hanci, Volkan |
|
dc.contributor.author |
Karakahya, Refika Hande |
|
dc.contributor.author |
Tas, Nilay |
|
dc.contributor.author |
Yagan, Ozgur |
|
dc.contributor.author |
Yurtlu, Bulent Serhan |
|
dc.date.accessioned |
2022-08-17T07:00:08Z |
|
dc.date.available |
2022-08-17T07:00:08Z |
|
dc.date.issued |
2015 |
|
dc.identifier.uri |
https://pubmed.ncbi.nlm.nih.gov/26564297/ |
|
dc.identifier.uri |
https://www.researchgate.net/publication/283792115_Intraocular_pressure_changes_associated_with_tracheal_extubation_Comparison_of_sugammadex_with_conventional_reversal_of_neuromuscular_blockade |
|
dc.identifier.uri |
http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2649 |
|
dc.description.abstract |
Objective: To compare the effects of neostigmine/atropine combination and sugammadex on intraocular pressure during tracheal extubation period.
Methods: The single-blind prospective randomised controlled study was conducted at Ordu University Research and Training Hospital from August to October 2014, and comprised patients who were randomly assigned to 2 groups according to the agent used for reversal of neuromuscular blockade. Group N received 0.05mgkg-1 neostigmine and 0.02 mgkg-1 atropine and the patients in Group S received 2mgkg-1 sugammadex intravenously. Heart rate, mean arterial pressure and intraocular pressure were measured at baseline, before the induction (T1), after the application of reversal agent (T2), and 1 (T3), 3 (T4), 5 (T5) and 10 (T6) minutes after the extubation. SPSS 16 was used for statistical analysis.
Results: There were 36 patients in the study; 18(50%) in each group. There was no significant difference between the groups in terms of age, gender and bodymass index (p>0.05 each). Intraocular pressure was significantly higher when the baseline level was compared with all measurement intervals in Group N (p<0.05 each). In Group S, it showed no significant difference at T2 (p>0.05) whereas it was significantly higher at all other measurement intervals (p<0.05 each). Intergroup comparisons showed statistically significant difference in heart rate and mean arterial pressure levels at T2 interval which were higher in Group N (p<0.01). Intraocular pressure levels at T2 and T3 intervals were significantly higher in Group N (p<0.01).
Conclusions: Lower end-extubation intraocular pressure levels were obtained when sugammadex was used as a neuromuscular block reversal agent in comparison with neostigmine-atropine combination. Sugammadex may be a better option for the reversal of neuromuscular blockade and intraocular pressure increase should be avoided in patients with glaucoma or penetrating eye injury. |
en_US |
dc.language.iso |
eng |
en_US |
dc.publisher |
PAKISTAN MEDICAL ASSOCPMA HOUSE, AGA KHAN III RD, KARACHI 00000, PAKISTAN |
en_US |
dc.rights |
info:eu-repo/semantics/openAccess |
en_US |
dc.subject |
LARYNGEAL MASK AIRWAYHEMODYNAMIC-RESPONSESSYSTEMIC ATROPINEANESTHESIAPROPOFOLDEXMEDETOMIDINEINTUBATIONSURGERYEYE |
en_US |
dc.subject |
NeostigmineAnaestheticsIntraocular pressureSugammadex |
en_US |
dc.title |
Intraocular pressure changes associated with tracheal extubation: Comparison of sugammadex with conventional reversal of neuromuscular blockade |
en_US |
dc.type |
article |
en_US |
dc.relation.journal |
65 |
en_US |
dc.contributor.department |
Ordu Üniversitesi |
en_US |
dc.contributor.authorID |
0000-0002-2227-194X |
en_US |
dc.contributor.authorID |
0000-0003-2093-9229 |
en_US |
dc.contributor.authorID |
0000-0003-3020-1586 |
en_US |
dc.identifier.volume |
11 |
en_US |
dc.identifier.issue |
1219 |
en_US |
dc.identifier.startpage |
1225 |
en_US |