dc.contributor.author |
Akar, Furuzan |
|
dc.contributor.author |
Celikyurt, Ipek Komsuoglu |
|
dc.contributor.author |
Erden, Faruk |
|
dc.contributor.author |
Kokturk, Sibel |
|
dc.contributor.author |
Mutlu, Oguz |
|
dc.contributor.author |
Ulak, Guner |
|
dc.date.accessioned |
2022-08-16T12:00:46Z |
|
dc.date.available |
2022-08-16T12:00:46Z |
|
dc.date.issued |
2015 |
|
dc.identifier.uri |
http://doi.org/10.1016/j.homp.2014.05.002 |
|
dc.identifier.uri |
http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2084 |
|
dc.description.abstract |
Backgound: Homeopathy is a medical theory and practice that asserts that disease can be cured by remedies that produce symptoms in a healthy person similar to those suffered by a patient with a malady.
Methods: The aim of this study was to investigate effects of homeopathic Anax imperator (dragonfly) (Anax-i 30c and Anax-i 200c) in the forced swim test (FST), elevated plus-maze (EPM) test, hot plate (HP) test and open field test and examined NPY1 receptor expression, in naive mice.
Results: In the FST, treatment with Anax-i 30c or Anax-i 200c significantly diminished immobility time while in EPM test, Anax-i 200c increased the percentage of time spent in open arms as well as the percentage of open arm/total arms. In the HP test, Anax-i 30c or Anax-i 200c decreased the total time mice spent licking their hind paws while in open field test, treatment with Anax-i 200c increased the total distance and speed mice traveled compared to the control group. Three weeks of daily injections with Anax-i 30c or Anax-i 200c caused significant weight loss in mice. Anax-i 30c or Anax-i 200c treatment significantly decreased NPY1 receptor expression, and Anax-i 30c also decreased NPY2 receptor expression.
Conclusion: These results suggest that the homeopathic Anax-i exerts antidepressant, anxiolytic and analgesic-like effects and causes hyperlocomotion and weight loss. |
en_US |
dc.language.iso |
eng |
en_US |
dc.publisher |
THIEME MEDICAL PUBL INC333 SEVENTH AVE, NEW YORK, NY 10001 |
en_US |
dc.relation.isversionof |
10.1016/j.homp.2014.05.002 |
en_US |
dc.rights |
info:eu-repo/semantics/closedAccess |
en_US |
dc.subject |
HomeopathyAnax imperatorAdipokinetic hormoneBehavioral modelsNeuroreceptorMice |
en_US |
dc.subject |
NEUROPEPTIDE-YFOS EXPRESSIONRAT FOREBRAINANTAGONISTSGENEANTICONVULSANTIDENTIFICATIONRECOVERYPEPTIDEODONATA |
en_US |
dc.title |
Effects of homeopathic Anax imperator on behavioural and pain models in mice |
en_US |
dc.type |
article |
en_US |
dc.relation.journal |
HOMEOPATHY |
en_US |
dc.contributor.department |
Ordu Üniversitesi |
en_US |
dc.contributor.authorID |
0000-0001-5636-3300 |
en_US |
dc.contributor.authorID |
0000-0003-0895-3490 |
en_US |
dc.contributor.authorID |
0000-0003-0952-0742 |
en_US |
dc.identifier.volume |
104 |
en_US |
dc.identifier.issue |
1 |
en_US |
dc.identifier.startpage |
15 |
en_US |
dc.identifier.endpage |
23 |
en_US |