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Expression of Epstein-Barr virus in children with sacrococcygeal pilonidal sinus determined by immunohistochemical methods

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dc.contributor.author Kacar, Ayper
dc.contributor.author Karakus, Esra
dc.contributor.author Karakus, Resul
dc.contributor.author Mambet, Ervin
dc.contributor.author Senayli, Atilla
dc.date.accessioned 2022-08-16T11:55:49Z
dc.date.available 2022-08-16T11:55:49Z
dc.date.issued 2016
dc.identifier.uri http://doi.org/10.1111/iwj.12286
dc.identifier.uri https://onlinelibrary.wiley.com/doi/10.1111/iwj.12286
dc.identifier.uri http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2052
dc.description.abstract In this study, we probed whether chronic infections of skin such as pilonidal sinus could be a potential site of Epstein-Barr virus (EBV) replication. Pilonidal sinus is associated with a high recurrence rate. Therefore, we decided to determine the role of EBV's presence to explain whether it is correlated with the recurrence of pilonidal sinuses. This study was conducted on 36 patient samples with sacrococcygeal pilonidal sinus. Samples were immunohistochemically stained for EBV, CD3 and CD20 expression. Thirty-six adolescents with pilonidal disease were evaluated. EBV-positive cells were located in dermis with high inflammatory activity. EBV-positive cells stained positive for the B-cell antigen CD20 and were detected in 10 of 36 (27%) pilonidal sinus specimens. Among those who had experienced a relapse, three were positive for EBV expression. In addition, EBV expression was detected in eight cases with severe inflammation, and in two with minimal or moderate inflammation. Our study advances the field by demonstrating that similar to gastrointestinal mucosa, skin could be a reservoir for EBV. EBV was found to be restricted to B cells in skin lesions, and it was found that skin lesions with severe inflammation showed higher frequency of EBV expression in comparison to minimal or moderately inflammed skin lesions. Additionally, recurrence was more frequently observed among EBV-positive cases. These findings point out for a role of EBV infection in the recurrence of pilonidal sinuses. en_US
dc.language.iso eng en_US
dc.publisher WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA en_US
dc.relation.isversionof 10.1111/iwj.12286 en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Epstein-Barr virus; Inflammation; Pilonidal sinus; Skin chronic inflammation en_US
dc.subject INFECTION en_US
dc.title Expression of Epstein-Barr virus in children with sacrococcygeal pilonidal sinus determined by immunohistochemical methods en_US
dc.type article en_US
dc.relation.journal INTERNATIONAL WOUND JOURNAL en_US
dc.contributor.department Ordu Üniversitesi en_US
dc.contributor.authorID 0000-0002-6114-9322 en_US
dc.identifier.volume 13 en_US
dc.identifier.issue 2 en_US
dc.identifier.startpage 265 en_US
dc.identifier.endpage 267 en_US


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