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The Effect of Tadalafil on Renal Fibrosis Induced by Ureteral Obstruction

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dc.contributor.author Ayyildiz, Ali
dc.contributor.author Ayyildiz, Sema Nur
dc.contributor.author Benli, Erdal
dc.contributor.author Cirrik, Selma
dc.contributor.author Kacar, Ayper
dc.contributor.author Karaguzel, Ersagun
dc.contributor.author Kokturk, Sibel
dc.contributor.author Noyan, Tevfik
dc.date.accessioned 2022-08-16T11:53:27Z
dc.date.available 2022-08-16T11:53:27Z
dc.date.issued 2016
dc.identifier.uri http://doi.org/10.7727/wimj.2016.518
dc.identifier.uri https://www.mona.uwi.edu/fms/wimj/article/3237
dc.identifier.uri http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2037
dc.description.abstract Objective: It has been reported that phosphodiesterase-5 (PDE5) inhibitors improve kidney functions during acute and chronic renal failure. This study aimed to determine the possible therapeutic effects of tadalafil, a specific PDE5 inhibitor, on renal fibrosis induced by unilateral ureteral obstruction (UUO). Methods: Male Sprague-Dawley rats were used and randomly divided into three groups (n=6) as sham-operated, UUO and tadalafil-treated (10 mg/72 h, ig) UUO (UUO+T) groups. UUO was induced by complete ligation of the left ureter and 14 days after surgery creatinine clearance, urinary cGMP, renal a-sma and TGF-β levels, as well as histologic changes, were observed in all animals. Results: UUO-induced renal fibrosis was confirmed by increased a-sma level, collagen deposition, tubular dilation, inflammatory cell infiltration and necrosis. An increased renal TGF-β level and decreased urinary cGMP level was also observed in obstructed animals in addition to reduced creatinine clearance. Tadalafil treatment, which restored urinary cGMP level, significantly attenuated the fibrotic changes and TGF-β increase in kidneys. Conclusion: This study suggests that tadalafil treatment ameliorates renal fibrosis by reducing TGF-β expression and may have important clinical relevance since tadalafil is currently used clinically to treat erectile dysfunction and pulmonary hypertension. en_US
dc.language.iso eng en_US
dc.publisher WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA en_US
dc.relation.isversionof 10.7727/wimj.2016.518 en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Alpha-smacGMPPDE5renal fibrosisTadalafilTGF-βureter obstruction en_US
dc.title The Effect of Tadalafil on Renal Fibrosis Induced by Ureteral Obstruction en_US
dc.type article en_US
dc.relation.journal ACTA PHYSIOLOGICA en_US
dc.contributor.department Ordu Üniversitesi en_US
dc.contributor.authorID 0000-0001-5636-3300 en_US
dc.contributor.authorID 0000-0001-8474-0185 en_US
dc.contributor.authorID 0000-0001-8485-1424 en_US
dc.contributor.authorID 0000-0002-2354-2713 en_US
dc.contributor.authorID 0000-0002-7733-0177 en_US
dc.contributor.authorID 0000-0003-3724-2516 en_US
dc.contributor.authorID 0000-0003-4270-0147 en_US
dc.identifier.volume 218 en_US
dc.identifier.startpage 11 en_US
dc.identifier.endpage 11 en_US


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