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Does causes 1800 MHz magnetic field application KRAS and P53 mutations in colon?: occurences histopatologically and microbiologically changes in colon

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dc.contributor.author Cayci, M.
dc.contributor.author Celikozlu, H.
dc.contributor.author Celikozlu, S.
dc.contributor.author Darcan, S.
dc.contributor.author Dayioglu, H.
dc.contributor.author Ece, E.
dc.contributor.author Kokturk, S.
dc.contributor.author Ozzaim, C.
dc.date.accessioned 2022-08-16T11:53:13Z
dc.date.available 2022-08-16T11:53:13Z
dc.date.issued 2016
dc.identifier.uri http://doi.org/10.5455/annalsmedres.2020.09.958
dc.identifier.uri https://www.ejmanager.com/mnstemps/134/134-1600027311.pdf?t=1638450826
dc.identifier.uri http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2035
dc.description.abstract Aim: The aim of this study was to determine effects of 1800 MHz magnetic field on amout of colonic Bactroides and Fusobacterium and colon pathology in rats and determination of KRAS and p53 gene mutation in colon. Materials and Methods: In the present study, three groups were prepared as control, sham and RFR. The RFR group rats were exposed to 1800 MHz GSM-like RFR for 12 weeks as 45 minutes per day. An electromagnetic energy generator was used to generate 1800 MHz RF radiation in the RFR group. At the end of experiments, colons were dissected from rats for histopathological examination and determination of KRAS and p53 mutations. Fecal speciments were collected for bacterial detection. DNA was isolated from fecal bacterias and colon. Results: No differences were observed between sham and control groups, histopathologically. Corrupted gland structure, mucosal edema and inflammatory cell infiltration were observed at mucosal epithelum in the RFR group. An increase in the amount of collagen and fibrosis were detected in the electromagnetic field group. Number of goblet cells showed a statistically significant decrease in electromagnetic field group compared to both the control and sham groups (P<0.05). The increase in the amount of Fusobacterium it was significantly higher in the RFR group compared to the control group. In the quantity of Bacteroides, no differences were observed between the groups. KRAS and Tp53 mutation analysis of all samples were found to be wild type, at the colon tissues. No significant difference observed between the control group and the electromagnetic field treated group. Conclusion: These results support, for 12 weeks 45 min/day exposure to GSM-like RFR caused histopathological damage in rat colon. Also, the amount of Fusobacterium is increased. But RFR exposure did not caused to KRAS and P53 mutations in colon tissue. en_US
dc.language.iso eng en_US
dc.publisher WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA en_US
dc.relation.isversionof 10.5455/annalsmedres.2020.09.958 en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Colon, histology, microbiology, mutation, radiofrequency radiation en_US
dc.title Does causes 1800 MHz magnetic field application KRAS and P53 mutations in colon?: occurences histopatologically and microbiologically changes in colon en_US
dc.type conferenceObject en_US
dc.relation.journal FEBS JOURNAL en_US
dc.contributor.department Ordu Üniversitesi en_US
dc.identifier.volume 283 en_US
dc.identifier.issue 156 en_US
dc.identifier.startpage 157 en_US


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