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Oxidative Stress Induced by Ureteral Obstruction and Tadalafil

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dc.contributor.author Ayyildiz, Ali
dc.contributor.author Ayyildiz, Sema Nur
dc.contributor.author Benli, Erdal
dc.contributor.author Cirakoglu, Abdullah
dc.contributor.author Cirrik, Selma
dc.contributor.author Germiyanoglu, Rustu Cankon
dc.contributor.author Noyan, Tevfik
dc.date.accessioned 2022-08-16T11:49:50Z
dc.date.available 2022-08-16T11:49:50Z
dc.date.issued 2017
dc.identifier.uri http://cms.galenos.com.tr/Uploads/Article_35784/jarem-7-11-En.pdf
dc.identifier.uri http://doi.org/10.5152/jarem.2017.1109
dc.identifier.uri http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2015
dc.description.abstract Objective: It has been reported that tadalafil, a specific phosphodiesterase-5 (PDE5) inhibitor, has an antioxidant effect besides its well-known vasoactive properties. This study aimed to determine the possible protective effects of tadalafil in managing renal oxidative stress induced by unilateral ureteral obstruction (UUO). Methods: Male Sprague-Dawley rats aged 2.5-3 months were randomly divided into 5 groups (n=8) as sham (P), partial obstruction (P), P+ tadalafil (PT), complete obstruction (C), and C+ tadalafil (CT). Animals in the PT and CT groups were administered with tadalafil (10 mg/kg, ig) just before the anesthesia. Twenty-four hours after the obstruction surgery, the animals were sacrificed. In the kidney homogenates, MDA and AOPP levels were examined in addition to SOD and CAT activities. Serum creatinine levels were also measured. Results: Both partial and complete obstruction caused a significant increase in the serum creatinine, tissue MDA and tissue AOPP levels. Although unchanged SOD activity, renal CAT activity decreased significantly in P and C groups. In tadalafil treated animals, serum creatinine, tissue MDA and AOPP levels, or renal SOD activity did not change compared to obstructed groups. However, the renal CAT activity increased in tadalafil-treated groups. A single-dose tadalafil treatment significantly restored renal CAT activity to the range of controls in the PT group. Conclusion: Although tadalafil did not affect renal oxidative stress induced by partial or complete UUO, elevation of CAT activity to control values in the PT group suggests that increasing doses or duration of tadalafil treatment might be protective for kidneys in UUO. en_US
dc.language.iso eng en_US
dc.publisher AVES, BUYUKDERE CAD 105-9, MECIDIYEKOY, SISLI, ISTANBUL 34394, TURKEY en_US
dc.relation.isversionof 10.5152/jarem.2017.1109 en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject PDE5; tadalafil; ureter; obstruction; oxidative stress en_US
dc.subject PHOSPHODIESTERASE TYPE 5; ISCHEMIA/REPERFUSION INJURY; INHIBITOR; EXPRESSION; RATS en_US
dc.title Oxidative Stress Induced by Ureteral Obstruction and Tadalafil en_US
dc.type article en_US
dc.relation.journal JOURNAL OF ACADEMIC RESEARCH IN MEDICINE-JAREM en_US
dc.contributor.department Ordu Üniversitesi en_US
dc.contributor.authorID 0000-0001-8474-0185 en_US
dc.contributor.authorID 0000-0001-8485-1424 en_US
dc.contributor.authorID 0000-0002-7733-0177 en_US
dc.contributor.authorID 0000-0002-8602-5836 en_US
dc.identifier.volume 7 en_US
dc.identifier.issue 1 en_US
dc.identifier.startpage 11 en_US
dc.identifier.endpage 15 en_US


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