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Circulating Glucose-Regulated Protein 78 Levels in Patients with Chronic Hepatitis B Infection

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dc.contributor.author Altuncekic Yildirim, Arzu
dc.contributor.author Calgin, Mustafa Kerem
dc.contributor.author Cetinkol, Yeliz
dc.contributor.author Cirrik, Selma
dc.contributor.author Noyan, Tevfik
dc.date.accessioned 2022-08-16T11:36:58Z
dc.date.available 2022-08-16T11:36:58Z
dc.date.issued 2018
dc.identifier.uri http://doi.org/10.4274/vhd.2018.0011
dc.identifier.uri http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/1969
dc.description.abstract Objectives: The role of endoplasmic reticulum (ER) stress in the pathogenesis of hepatitis B virus (HBV) has been reported. However, serum levels of glucose-regulated protein (GRP) 78 which is an ER stress marker both in tissue and circulation have not been reported yet. This study aimed to evaluate serum GRP78 levels in patients with chronic HBV infection. Materials and Methods: A total of 60 patients with HBV infection and 50 control subjects were included in this study. According to HBV-DNA levels, patients with HBV infection were subdivided into low, mild and high HBV-DNA subgroups (n=20, in each). Serum GRP78 level was measured by ELISA and then correlation analysis was performed between GRP78 and alanine aminotransferase (ALT), aspartate aminotransferase (AST), HBV-DNA or hepatitis B surface antigen (HBsAg). Results: HBsAg levels were significantly higher in each HBV subgroup compared to controls. ALT and AST levels were significantly increased in the high HBV-DNA subgroup. There was no significant difference in serum GRP78 level between controls and HBV subgroups and no correlation between serum GRP78 levels andother variables. Conclusion: As a result of our study, there was no relationship between the serum level of GRP78 and the HBV infection parameters. Since ER stress is an important mechanism in HBV-related liver injury, other ER stress markers, such as GRP94, might be examined in future studies. en_US
dc.language.iso eng en_US
dc.publisher GALENOS YAYINCILIK, ERKAN MOR, MOLLA GURANI CAD 21-1, FINDIKZADE, ISTANBUL 34093, TURKEY en_US
dc.relation.isversionof 10.4274/vhd.2018.0011 en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Hepatitis B; glucose-regulated protein 78; endoplasmic reticulum stress en_US
dc.title Circulating Glucose-Regulated Protein 78 Levels in Patients with Chronic Hepatitis B Infection en_US
dc.type article en_US
dc.relation.journal VIRAL HEPATIT DERGISI-VIRAL HEPATITIS JOURNAL en_US
dc.contributor.department Ordu Üniversitesi en_US
dc.contributor.authorID 0000-0001-8474-0185 en_US
dc.contributor.authorID 0000-0002-7733-0177 en_US
dc.contributor.authorID 0000-0003-1141-9838 en_US
dc.contributor.authorID 0000-0003-4236-6177 en_US
dc.contributor.authorID 0000-0003-4940-4498 en_US
dc.identifier.volume 24 en_US
dc.identifier.issue 3 en_US
dc.identifier.startpage 85 en_US
dc.identifier.endpage 89 en_US


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