Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/5344
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dc.contributor.authorNguyen, Nguyen K.-
dc.contributor.authorDeehan, Edward C.-
dc.contributor.authorZhang, Zhengxiao-
dc.contributor.authorJin, Mingliang-
dc.contributor.authorBaskota, Nami-
dc.contributor.authorPerez-Munoz, Maria Elisa-
dc.contributor.authorCole, Janis-
dc.contributor.authorTuncil, Yunus E.-
dc.contributor.authorSeethaler, Benjamin-
dc.contributor.authorWang, Ting-
dc.contributor.authorLaville, Martine-
dc.contributor.authorDelzenne, Nathalie M.-
dc.contributor.authorBischoff, Stephan C.-
dc.contributor.authorHamaker, Bruce R.-
dc.contributor.authorMartinez, Ines-
dc.contributor.authorKnights, Dan-
dc.contributor.authorBakal, Jeffrey A.-
dc.contributor.authorPrado, Carla M.-
dc.contributor.authorWalter, Jens-
dc.date.accessioned2024-03-26T07:29:20Z-
dc.date.available2024-03-26T07:29:20Z-
dc.date.issued2020-
dc.identifier.citationNguyen, NK., Deehan, EC., Zhang, ZX., Jin, ML., Baskota, N., Perez-Muñoz, ME., Cole, J., Tuncil, YE., Seethaler, B., Wang, T., Laville, M., Delzenne, NM., Bischoff, SC., Hamaker, BR., Martínez, I., Knights, D., Bakal, JA., Prado, CM., Walter, J. (2020). Gut microbiota modulation with long-chain corn bran arabinoxylan in adults with overweight and obesity is linked to an individualized temporal increase in fecal propionate. Microbiome, 8(1). https://doi.org/10.1186/s40168-020-00887-wen_US
dc.identifier.issn2049-2618-
dc.identifier.urihttp://dx.doi.org/10.1186/s40168-020-00887-w-
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000565342100001-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/5344-
dc.descriptionWoS Categories: Microbiologyen_US
dc.descriptionWeb of Science Index: Science Citation Index Expanded (SCI-EXPANDED)en_US
dc.descriptionResearch Areas: Microbiologyen_US
dc.description.abstractBackground: Variability in the health effects of dietary fiber might arise from inter-individual differences in the gut microbiota's ability to ferment these substrates into beneficial metabolites. Our understanding of what drives this individuality is vastly incomplete and will require an ecological perspective as microbiomes function as complex inter-connected communities. Here, we performed a parallel two-arm, exploratory randomized controlled trial in 31 adults with overweight and class-I obesity to characterize the effects of long-chain, complex arabinoxylan (n= 15) at high supplementation doses (female: 25 g/day; male: 35 g/day) on gut microbiota composition and short-chain fatty acid production as compared to microcrystalline cellulose (n= 16, non-fermentable control), and integrated the findings using an ecological framework. Results: Arabinoxylan resulted in a global shift in fecal bacterial community composition, reduced alpha-diversity, and the promotion of specific taxa, including operational taxonomic units related toBifidobacterium longum,Blautia obeum, andPrevotella copri. Arabinoxylan further increased fecal propionate concentrations (p= 0.012, Friedman's test), an effect that showed two distinct groupings of temporal responses in participants. The two groups showed differences in compositional shifts of the microbiota (p <= 0.025, PERMANOVA), and multiple linear regression (MLR) analyses revealed that the propionate response was predictable through shifts and, to a lesser degree, baseline composition of the microbiota. Principal components (PCs) derived from community data were better predictors in MLR models as compared to single taxa, indicating that arabinoxylan fermentation is the result of multi-species interactions within microbiomes. Conclusion: This study showed that long-chain arabinoxylan modulates both microbiota composition and the output of health-relevant SCFAs, providing information for a more targeted application of this fiber. Variation in propionate production was linked to both compositional shifts and baseline composition, with PCs derived from shifts of the global microbial community showing the strongest associations. These findings constitute a proof-of-concept for the merit of an ecological framework that considers features of the wider gut microbial community for the prediction of metabolic outcomes of dietary fiber fermentation. This provides a basis to personalize the use of dietary fiber in nutritional application and to stratify human populations by relevant gut microbiota features to account for the inconsistent health effects in human intervention studies.en_US
dc.description.sponsorshipjoint European Research Area and Joint Programming Initiative-A Healthy Diet for a Healthy Life (ERA-HDHL) grant (Biomarkers for Nutrition and Health; FiberTAG project); Canadian Institutes of Health Research (CIHR); Campus Alberta Innovation Program (CAIP)en_US
dc.language.isoengen_US
dc.publisherBMC-LONDONen_US
dc.relation.isversionof10.1186/s40168-020-00887-wen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectArabinoxylan, Dietary fiber, Gut microbiota, Inter-individual variability, Overweight adults, Short-chain fatty acidsen_US
dc.subjectDIETARY FIBER STRUCTURES, IN-VITRO FERMENTATION, FATTY-ACIDS, INTESTINAL MICROBIOTA, HUMAN HEALTH, BODY-WEIGHT, R-PACKAGE, SP-NOV, DEGRADATION, OLIGOSACCHARIDESen_US
dc.titleGut microbiota modulation with long-chain corn bran arabinoxylan in adults with overweight and obesity is linked to an individualized temporal increase in fecal propionateen_US
dc.typearticleen_US
dc.relation.journalMICROBIOMEen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0001-8919-3977en_US
dc.contributor.authorID0000-0002-3609-5641en_US
dc.contributor.authorID0000-0003-4234-1746en_US
dc.contributor.authorID0000-0002-6977-4309en_US
dc.contributor.authorID0000-0003-1754-172Xen_US
dc.contributor.authorID0000-0001-7697-1418en_US
dc.contributor.authorID0000-0002-3658-2554en_US
dc.contributor.authorID0000-0002-6977-4309en_US
dc.contributor.authorID0000-0002-5935-3236en_US
dc.identifier.volume8en_US
dc.identifier.issue1en_US
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