Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/5274
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dc.contributor.authorKaracaoglan, Volkan-
dc.contributor.authorAda, Ahmet Oguz-
dc.contributor.authorBilgen, Serdar-
dc.contributor.authorCetinkaya, Guzide Tugba-
dc.contributor.authorSoydas, Emre-
dc.contributor.authorKunak, Celalettin Semih-
dc.contributor.authorAlpar, Sibel Meryem-
dc.contributor.authorGulhan, Meral-
dc.contributor.authorIscan, Mumtaz-
dc.date.accessioned2024-03-26T06:59:01Z-
dc.date.available2024-03-26T06:59:01Z-
dc.date.issued2017-
dc.identifier.citationKaracaoglan, V., Ada, AO., Bilgen, S., Çetinkaya, GT., Soydas, E., Kunak, CS., Alpar, SM., Gülhan, M., Iscan, M. (2017). Xenobiotic/drug metabolizing enzyme and TP53 polymorphisms and clinical outcome in advanced nonsmall cell lung cancer patients. Turk. J. Med. Sci., 47(2), 554-562. https://doi.org/10.3906/sag-1602-77en_US
dc.identifier.issn1300-0144-
dc.identifier.issn1303-6165-
dc.identifier.urihttp://dx.doi.org/10.3906/sag-1602-77-
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000399829700027-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/5274-
dc.descriptionWoS Categories: Medicine, General & Internalen_US
dc.descriptionWeb of Science Index: Science Citation Index Expanded (SCI-EXPANDED)en_US
dc.descriptionResearch Areas: General & Internal Medicineen_US
dc.description.abstractBackground/aim: The association between polymorphisms of xenobiotic/drug metabolizing enzymes and TP53 and response to chemotherapy and survival of patients with nonsmall cell lung cancer (NSCLC) are limited and inconclusive. In this study, CYP2E1*5B, CYP2E1*6, CYP2E1*7B, GSTO1 (A140D), and TP53 (Arg72Pro) polymorphisms and response to platinum-based chemotherapy and survival in 137 advanced stage NSCLC patients were investigated. Materials and methods: Genetic polymorphism analyses were determined by polymerase chain reaction (PCR) coupled with restriction fragment length polymorphism (RFLP). Results: The patients with TP53 Pro/Pro variant were more likely to be resistant to chemotherapy than those with Arg/Arg variants with marginal significance (P = 0.066). We also analyzed these gene variants in combination with CYP1A1 (Ile462Val), CYP1B1 (Asn453Ser), GSTM1, GSTP1 exon 5 (Ile105Val), and GSTP1 exon 6 (Ala114Val) and GSTT1 polymorphic genes that we have previously genotyped in the same patients (Ada et al., Neoplasma, 57, 512-527, 2010). The multivariate analysis revealed that adjusted hazard ratio (HR) of death of the combined variant genotypes of TP53 (Arg72Pro, Pro72Pro) and CYP1A1 (Ile462Val, Val462Val) increased significantly as compared to wild-type genotypes (HR, 6.03; 95% CI, 1.39-26.04, P = 0.016). Conclusion: These results show that combined variant genotypes of TP53 (Arg72Pro, Pro72Pro) and CYP1A1 (Ile/Val, Val/Val) are associated with worsening of survival in NSCLC patients.en_US
dc.description.sponsorshipResearch Funds of Ankara University [2008-08-03-006HPD, 10A3336002]en_US
dc.language.isoengen_US
dc.publisherTubitak Scientific & Technological Research Council Turkey-ANKARAen_US
dc.relation.isversionof10.3906/sag-1602-77en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectXenobiotic/drug metabolizing enzymes, TP53, polymorphisms, response to chemotherapy, survival, nonsmall cell lung canceren_US
dc.subjectGERM-LINE POLYMORPHISMS, GENETIC POLYMORPHISMS, P53 GENE, CODON-72 POLYMORPHISM, TRANSFERASE GENES, CIGARETTE-SMOKING, 2E1 POLYMORPHISM, MDM2 SNP309, ASSOCIATION, RISKen_US
dc.titleXenobiotic/drug metabolizing enzyme and TP53 polymorphisms and clinical outcome in advanced nonsmall cell lung cancer patientsen_US
dc.typearticleen_US
dc.relation.journalTURKISH JOURNAL OF MEDICAL SCIENCESen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0001-9987-0572en_US
dc.identifier.volume47en_US
dc.identifier.issue2en_US
dc.identifier.startpage554en_US
dc.identifier.endpage562en_US
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