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DC Field | Value | Language |
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dc.contributor.author | Durukan, Yasin | - |
dc.contributor.author | Bala, Mehmet Murat | - |
dc.contributor.author | Sahin, Abdullah Alper | - |
dc.contributor.author | Firat, Tulin | - |
dc.contributor.author | Bugdayci, Guler | - |
dc.contributor.author | Ozturan, Kutay Engin | - |
dc.date.accessioned | 2024-03-26T06:56:09Z | - |
dc.date.available | 2024-03-26T06:56:09Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Durukan, Y., Bala, MM., Sahin, AA., Firat, T., Bugdayci, G., Özturan, KE. (2022). The effect of astaxanthine on ischemia-reperfusion injury in a rat model. J. Orthop. Sci., 27(5), 1132-1138. https://doi.org/10.1016/j.jos.2021.05.014 | en_US |
dc.identifier.issn | 0949-2658 | - |
dc.identifier.issn | 1436-2023 | - |
dc.identifier.uri | http://dx.doi.org/10.1016/j.jos.2021.05.014 | - |
dc.identifier.uri | https://www.webofscience.com/wos/woscc/full-record/WOS:000890114800029 | - |
dc.identifier.uri | http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/5259 | - |
dc.description | WoS Categories: Orthopedics | en_US |
dc.description | Web of Science Index: Science Citation Index Expanded (SCI-EXPANDED) | en_US |
dc.description | Research Areas: Orthopedics | en_US |
dc.description.abstract | Background: We aimed to compare biochemical and histopathological findings of astaxanthin's potential effects on oxidative stress in ischemia/reperfusion damage (I/R). Methods: Thirty-two rats were randomly divided into four groups: control group; I/R group; I/ R + treatment group; drug group. Astaxanthin was orally administered to groups C and D for 14 days. In groups B and C, the femoral artery was clamped for 2 h to form ischemia. The clamp was opened, and reperfusion was performed for 1 h. In all groups, 4 ml of blood sample through intracardiac puncture and gastrocnemius muscle tissue samples were collected. Serum and tissue samples were analyzed by measuring malondialdehyde (MDA), superoxide dismutase (SOD), total antioxidant capacity (TAC), and total oxidative level (TOL). Necrosis, inflammation, and caspase-3 in muscle tissue collected for histopathological examination were evaluated. Results: Tissue MDA, SOD and TOL values significantly differed between groups. Serum MDA, SOD, TOL and TAC values significantly differed between groups. On necrosis examination, there was a significant difference between groups B and C. Although signs of inflammation significantly differed between groups, there was no significant difference between groups A and C and groups A and D. Although there was a significant difference in caspase-3 results between groups, there was no significant difference between groups A and C. Conclusions: The use of astaxanthin before and after surgery showed preventive or therapeutic effects against I/R damage. (C) 2021 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | ELSEVIER-AMSTERDAM | en_US |
dc.relation.isversionof | 10.1016/j.jos.2021.05.014 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Astaxanthin, Ischemia/reperfusion, Oxidative stress | en_US |
dc.subject | OXIDATIVE STRESS, SKELETAL-MUSCLE, DAMAGE, GENOTOXICITY, PROTECTS | en_US |
dc.title | The effect of astaxanthine on ischemia-reperfusion injury in a rat model | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF ORTHOPAEDIC SCIENCE | en_US |
dc.contributor.department | Ordu Üniversitesi | en_US |
dc.contributor.authorID | 0000-0002-7213-5647 | en_US |
dc.contributor.authorID | 0000-0002-3363-8364 | en_US |
dc.identifier.volume | 27 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 1132 | en_US |
dc.identifier.endpage | 1138 | en_US |
Appears in Collections: | Cerrahi Tıp Bilimleri |
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