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Title: | Effects of insulin-like growth factor-1 on random pattern skin flap survival in rats |
Authors: | Haktanir, Nurten Turhan Yilmaz, Guray Bozkurt, Mehmet Fatih Demir, Yavuz Ordu Üniversitesi 0000-0002-0600-2504 |
Keywords: | Insulin-Like Growth Factor I, Surgical Flaps, Survival, Skin, Rats HORMONE, ACTIVATION, MIGRATION, PATHWAYS, REPAIR, MTOR |
Issue Date: | 2016 |
Publisher: | ACTA CIRURGICA BRASILEIRA-SAO PAULO |
Citation: | Haktanir, NT., Yilmaz, G., Bozkurt, MF., Demir, Y. (2016). Effects of insulin-like growth factor-1 on random pattern skin flap survival in rats. Acta Cir. Bras., 31(8), 513-519. https://doi.org/10.1590/S0102-865020160080000003 |
Abstract: | PURPOSE: To investigate the effects of pharmacological delay with insulin-like growth factor-1 (IGF-1) on skin flap survival. METHODS: Thirty Sprague-Dawley rats were submitted to dorsal skin flap (3x9 cm). Seven days before the surgery, the animals were subdivided into three groups of 10 rats. In group 1 (controls), no injection was done. Seven days before the elevation, saline had been injected to the marked skin flap area in group 2 (sham group), and group 3 (experimental group) underwent a pharmacological delay with subcutaneous IGF-1 injections. On the seventh postoperative day, flap area was analyzed for survival. Tissue samples were obtained for histological and biochemical evaluations. RESULTS: Survival rates were 43.55 +/- 16%, 21.40 +/- 8%, and 43.12 +/- 14% in groups 1, 2, and 3, respectively. Differences between group 2 and other groups were statistically significant. No significant difference was detected between all three groups for tissue or plasma vascular endothelial growth factor (VEGF) levels. There was no significant histological difference between groups. CONCLUSION: Although a single injection of insulin-like growth factor-1 (IGF-1) did not significantly increase flap survival, its wound healing features are still encouraging and further meticulously planned studies, especially with repeated applications or controlled-release methods, and combinations with binding protein are required. |
Description: | WoS Categories: Surgery Web of Science Index: Science Citation Index Expanded (SCI-EXPANDED) Research Areas: Surgery |
URI: | http://dx.doi.org/10.1590/S0102-865020160080000003 https://www.webofscience.com/wos/woscc/full-record/WOS:000383883900003 http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/5211 |
ISSN: | 0102-8650 1678-2674 |
Appears in Collections: | Dahili Tıp Bilimleri |
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