Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/5202
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dc.contributor.authorUstun, Elvan-
dc.contributor.authorSahin, Neslihan-
dc.contributor.authorOzdemir, Ilknur-
dc.contributor.authorGunal, Selami-
dc.contributor.authorGurbuez, Nevin-
dc.contributor.authorOzdemir, Ismail-
dc.contributor.authorSemeril, David-
dc.date.accessioned2024-03-26T06:48:04Z-
dc.date.available2024-03-26T06:48:04Z-
dc.date.issued2023-
dc.identifier.citationUstun, E., Sahin, N., Özdemir, I., Günal, S., Gürbuez, N., Özdemir, I., Sémeril, D. (2023). Design, synthesis, antimicrobial activity and molecular docking study of cationic bis-benzimidazole-silver(I) complexes. Arch. Pharm., 356(10). https://doi.org/10.1002/ardp.202300302en_US
dc.identifier.issn0365-6233-
dc.identifier.issn1521-4184-
dc.identifier.urihttp://dx.doi.org/10.1002/ardp.202300302-
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:001040549300001-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/5202-
dc.descriptionWoS Categories: Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacyen_US
dc.descriptionWeb of Science Index: Science Citation Index Expanded (SCI-EXPANDED)en_US
dc.descriptionResearch Areas: Pharmacology & Pharmacy; Chemistryen_US
dc.description.abstractTwo series of bis(1-alkylbenzimidazole)silver(I) nitrate and bis(1-alkyl-5,6-dimethylbenzimidazole)silver(I) nitrate complexes, in which the alkyl substituent is either an allyl, a 2-methylallyl, an isopropyl or a 3-methyloxetan-3-yl-methyl chain, were synthesized and fully characterized. The eight N-coordinated silver(I) complexes were screened for both antimicrobial activities against Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter baumannii) and Gram-positive (Staphylococcus aureus, Staphylococcus aureus MRSA, and Enterococcus faecalis) bacteria and antifungal activities against Candida albicans and Candida glabrata strains. Moderate minimal inhibitory concentrations (MIC) of 0.087 & mu;mol/mL were found when the Gram-negative and Gram-positive bacteria were treated with the silver complexes. Nevertheless, MIC values of 0.011 & mu;mol/mL, twice lower than for the well-known fluconazole, against the two fungi were measured. In addition, molecular docking was carried out with the structure of Escherichia coli DNA gyrase and CYP51 from the pathogen Candida glabrata with the eight organometallic complexes, and molecular reactivity descriptors were calculated with the density functional theory-based calculation methods.en_US
dc.description.sponsorshipScientific Research Project Fund of Sivas Cumhuriyet University [F-461]en_US
dc.language.isoengen_US
dc.publisherWILEY-V C H VERLAG GMBH-WEINHEIMen_US
dc.relation.isversionof10.1002/ardp.202300302en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectantifungal activity, antimicrobial activity, benzimidazole, molecular docking, silveren_US
dc.subjectBENZIMIDAZOLE DERIVATIVES, BIOLOGICAL-PROPERTIES, ENERGY, APPROXIMATION, UPDATEen_US
dc.titleDesign, synthesis, antimicrobial activity and molecular docking study of cationic bis-benzimidazole-silver(I) complexesen_US
dc.typearticleen_US
dc.relation.journalARCHIV DER PHARMAZIEen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0002-0587-7261en_US
dc.contributor.authorID0000-0001-6325-0216en_US
dc.contributor.authorID0000-0002-2582-4191en_US
dc.identifier.volume356en_US
dc.identifier.issue10en_US
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