Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/5168
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dc.contributor.authorDede, Figen Ongoz-
dc.contributor.authorGokmenoglu, Ceren-
dc.contributor.authorTurkmen, Emrah-
dc.contributor.authorDogan, Seyma Bozkurt-
dc.contributor.authorAyhan, Burhanettin Sertac-
dc.contributor.authorYildirim, Kubilay-
dc.date.accessioned2024-03-26T06:43:24Z-
dc.date.available2024-03-26T06:43:24Z-
dc.date.issued2023-
dc.identifier.citationDede, FÖ., Gokmenoglu, C., Türkmen, E., Dogan, SB., Ayhan, BS., Yildirim, K. (2023). Six miRNA expressions in the saliva of smokers and non-smokers with periodontal disease. J. Periodont. Res., 58(1), 195-203. https://doi.org/10.1111/jre.13081en_US
dc.identifier.issn0022-3484-
dc.identifier.issn1600-0765-
dc.identifier.urihttp://dx.doi.org/10.1111/jre.13081-
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000912470600001-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/5168-
dc.descriptionWoS Categories: Dentistry, Oral Surgery & Medicineen_US
dc.descriptionWeb of Science Index: Science Citation Index Expanded (SCI-EXPANDED)en_US
dc.descriptionResearch Areas: Dentistry, Oral Surgery & Medicineen_US
dc.description.abstractBackgroundIt has been stated that microRNA (miRNA) plays an important role in development, homeostasis, and immune functions, and abnormal miRNA expression may cause faster disease progression. ObjectiveThe aim of this study was to determine miR-203, miR-142-3p, miR-146a, miR-146b, miR-155, and miR-29b gene expressions in the saliva of smokers and non-smokers with the periodontal disease before and after non-surgical periodontal therapy (NSPT). MethodsA total of 90 individuals, 30 with periodontitis, 30 with gingivitis, and 30 periodontally healthy (control group), were included. These three groups were divided into subgroups as smoking and non-smoking individuals, with 15 people in each group. NSPT was applied to patients with periodontitis and gingivitis. Saliva samples and clinical parameters were obtained at baseline and repeated 6 weeks after NSPT. ResultsSaliva miR-203, miR-142-3p, miR-146a, miR-146b, and miR-155 gene expressions were significantly upregulated in patients with periodontal disease compared to the control group both in smokers and non-smokers, and also these miRNAs' gene expressions were significantly higher in the periodontitis group than in the gingivitis group at baseline (p < .05). A significant increase in saliva miR-142-3p expression was detected in all groups of smokers compared to non-smokers (p < .05). Although there was a decrease in salivary miRNAs gene expressions with the treatment, it was not statistically significant (p > .05). ConclusionsThese results suggest that salivary miR-146a, miR-146b, miR142-3p, miR-155, and miR-203 gene expressions increased with the progression of periodontal disease, but unchanged after periodontal treatment. Moreover, smoking may contribute to an increase in the levels of salivary miR-142-3p in the periodontal health and disease.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [318S106]en_US
dc.language.isoengen_US
dc.publisherWILEY-HOBOKENen_US
dc.relation.isversionof10.1111/jre.13081en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectgingivitis, miRNA, periodontal therapy, periodontitis, smokingen_US
dc.subjectMICRORNA EXPRESSION, GINGIVAL, SMOKING, CLASSIFICATION, THERAPY, TISSUEen_US
dc.titleSix miRNA expressions in the saliva of smokers and non-smokers with periodontal diseaseen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF PERIODONTAL RESEARCHen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0001-5670-6430en_US
dc.contributor.authorID0000-0002-3803-7189en_US
dc.contributor.authorID0000-0003-3834-0396en_US
dc.contributor.authorID0000-0001-5166-2109en_US
dc.identifier.volume58en_US
dc.identifier.issue1en_US
dc.identifier.startpage195en_US
dc.identifier.endpage203en_US
Appears in Collections:Periodontoloji

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