Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/5165
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dc.contributor.authorCihan, Murat-
dc.contributor.authorDogan, Ozlem-
dc.contributor.authorCeran Serdar, Ceyhan-
dc.contributor.authorAltuncekic Yildirim, Arzu-
dc.contributor.authorKurt, Celali-
dc.contributor.authorSerdar, Muhittin A.-
dc.date.accessioned2024-03-26T06:43:00Z-
dc.date.available2024-03-26T06:43:00Z-
dc.date.issued2022-
dc.identifier.citationCihan, M., Dogan, Ö., Serdar, CC., Yildirim, AA., Kurt, C., Serdar, MA. (2022). Kynurenine pathway in Coronavirus disease (COVID-19): Potential role in prognosis. J. Clin. Lab. Anal., 36(3). https://doi.org/10.1002/jcla.24257en_US
dc.identifier.issn0887-8013-
dc.identifier.issn1098-2825-
dc.identifier.urihttp://dx.doi.org/10.1002/jcla.24257-
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000748294600001-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/5165-
dc.descriptionWoS Categories: Medical Laboratory Technologyen_US
dc.descriptionWeb of Science Index: Science Citation Index Expanded (SCI-EXPANDED)en_US
dc.descriptionResearch Areas: Medical Laboratory Technologyen_US
dc.description.abstractBackground It is known that inflammatory responses play an important role in the pathophysiology of COVID-19. Aims In this study, we aimed to examine the role of kynurenine (KYN) metabolism on the severity of COVID-19 disease AQ5. Materials & Methods Seventy COVID-19 patients of varying severity and 30 controls were included in the study. In addition to the classical laboratory parameters, KYN, tryptophan (TRP), kynurenic acid (KYNA), 3 hydroxykynurenine (3OHKYN), quinolinic acid (QA), and picolinic acid (PA) were measured with mass spectrometry. Results TRP, KYN, KYN:TRP ratio, KYNA, 3OHKYN, PA, and QA results were found to be significantly different in COVID-19 patients (p < 0.001 for all). The KYN:TRP ratio and PA of severe COVID-19 patients was statistically higher than that of mild-moderate COVID-19 patients (p < 0.001 for all). When results were examined, statistically significant correlations with KYN:TRP ratio, IL-6, ferritin, and procalcitonin were only found in COVID-19 patients. ROC analysis indicated that highest AUC values were obtained by KYN:TRP ratio and PA (0.751 vs 0.742). In determining the severity of COVID-19 disease, the odd ratios (and confidence intervals) of KYN:TRP ratio and PA levels that were adjusted according to age, gender, and comorbidity were determined to be 1.44 (1.1-1.87, p = 0.008) and 1.06 (1.02-1.11, p = 0.006), respectively. Discussion & Conclusion According to the results of this study, KYN metabolites play a role in the pathophysiology of COVID-19, especially KYN:TRP ratio and PA could be markers for identification of severe COVID-19 cases.en_US
dc.language.isoengen_US
dc.publisherWILEY-HOBOKENen_US
dc.relation.isversionof10.1002/jcla.24257en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcoronavirus-19 disease (COVID-19), kynurenine pathway, prognosisen_US
dc.subjectTRYPTOPHAN, RECEPTORen_US
dc.titleKynurenine pathway in Coronavirus disease (COVID-19): Potential role in prognosisen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF CLINICAL LABORATORY ANALYSISen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0003-4419-4508en_US
dc.contributor.authorID0000-0003-1141-9838en_US
dc.contributor.authorID0000-0001-6611-7226en_US
dc.contributor.authorID0000-0002-3014-748Xen_US
dc.contributor.authorID0000-0003-3078-999Xen_US
dc.contributor.authorID0000-0002-2921-7030en_US
dc.identifier.volume36en_US
dc.identifier.issue3en_US
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