Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/5099
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dc.contributor.authorKaramanli, Harun-
dc.contributor.authorKiyici, Aysel-
dc.contributor.authorArik, Bilal-
dc.contributor.authorEfe, Duran-
dc.contributor.authorAkgedik, Recep-
dc.date.accessioned2024-03-26T06:34:37Z-
dc.date.available2024-03-26T06:34:37Z-
dc.date.issued2016-
dc.identifier.citationKaramanli, H., Kiyici, A., Arik, B., Efe, D., Akgedik, R. (2016). Influence of obstructive sleep apnea on ischemia-modified albumin levels and carotid intima-media thickness. J. Invest. Med., 64(5), 1035-1041. https://doi.org/10.1136/jim-2016-000063en_US
dc.identifier.issn1081-5589-
dc.identifier.issn1708-8267-
dc.identifier.urihttp://dx.doi.org/10.1136/jim-2016-000063-
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000400331300009-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/5099-
dc.descriptionWoS Categories: Medicine, General & Internal; Medicine, Research & Experimentalen_US
dc.descriptionWeb of Science Index: Science Citation Index Expanded (SCI-EXPANDED)en_US
dc.descriptionResearch Areas: General & Internal Medicine; Research & Experimental Medicineen_US
dc.description.abstractObstructive sleep apnea (OSA) is associated with an increased risk of atherosclerosis. Carotid intima-media thickness (CIMT) is strongly associated with the presence of significant risk factors for cardiovascular disturbances. A disturbance in the oxidative/antioxidative balance is involved in the pathogenesis of OSA and cardiovascular diseases. Ischemia-modified albumin (IMA) is suggested as a novel marker of oxidative stress; IMA can be defined as decreased binding of transitional metal ions to serum albumin in oxidative status. The purpose of this research was to evaluate the influence of OSA on IMA levels and CIMT. In total, 61 individuals with OSA with no comorbidities and 24 healthy controls with a similar body mass index and age were enrolled in this study. Serum levels of IMA, CIMT (estimated radiologically), and polysomnographic parameters, were determined and interpreted. Serum IMA levels were significantly higher in individuals with OSA compared with the control group (p=0.0003). CIMT was significantly higher in the OSA group compared with the control group (0.88 +/- 0.26 mm vs 0.75 +/- 0.17 mm, p=0.005). The CIMT and serum IMA levels were positively correlated with the apnea-hypopnea index (r=0.35 and r=0.32, respectively), and with the oxygen desaturation index (r=0.34 and r=0.29, respectively) at baseline. Increased IMA levels and CIMT may be related to increased oxidative stress and risk of atherosclerosis in individuals with OSA.en_US
dc.description.sponsorshipMevlana University [2015/089]en_US
dc.language.isoengen_US
dc.publisherBMJ PUBLISHING GROUP-LONDONen_US
dc.relation.isversionof10.1136/jim-2016-000063en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectARTERY WALL THICKNESS, MYOCARDIAL-ISCHEMIA, SERUM-ALBUMIN, CARDIOVASCULAR-DISEASES, INFLAMMATORY MARKERS, ENDOTHELIAL FUNCTION, PULMONARY-EMBOLISM, OXIDATIVE STRESS, RISK-FACTOR, ATHEROSCLEROSISen_US
dc.titleInfluence of obstructive sleep apnea on ischemia-modified albumin levels and carotid intima-media thicknessen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF INVESTIGATIVE MEDICINEen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.identifier.volume64en_US
dc.identifier.issue5en_US
dc.identifier.startpage1035en_US
dc.identifier.endpage1041en_US
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