Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/5094
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dc.contributor.authorKaraman, Suleyman-
dc.contributor.authorOzkan, Berna-
dc.contributor.authorYazir, Yusufhan-
dc.contributor.authorYardimoglu, Melda-
dc.contributor.authorGok, Mustafa-
dc.contributor.authorKara, Ozgur-
dc.contributor.authorVural, Cigdem-
dc.contributor.authorRencber, Selenay-
dc.contributor.authorEmek, Salih K.-
dc.date.accessioned2024-03-26T06:34:08Z-
dc.date.available2024-03-26T06:34:08Z-
dc.date.issued2016-
dc.identifier.citationKaraman, S., Ozkan, B., Yazir, Y., Yardimoglu, M., Gok, M., Kara, O., Vural, C., Rencber, S., Emek, SK. (2016). Comparison of hyperbaric oxygen versus iloprost treatment in an experimental rat central retinal artery occlusion model. Graefes Arch. Clin. Exp. Ophthalmol., 254(11), 2209-2215. https://doi.org/10.1007/s00417-016-3444-5en_US
dc.identifier.issn0721-832X-
dc.identifier.issn1435-702X-
dc.identifier.urihttp://dx.doi.org/10.1007/s00417-016-3444-5-
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000387128900017-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/5094-
dc.descriptionWoS Categories: Ophthalmologyen_US
dc.descriptionWeb of Science Index: Science Citation Index Expanded (SCI-EXPANDED)en_US
dc.descriptionResearch Areas: Ophthalmologyen_US
dc.description.abstractCentral retinal artery occlusion (CRAO) is one of the serious ophthalmological emergencies with poor visual prognosis. Iloprost is a stable prostacyclin analogue and has prominent anti-edema, anti-inflammatory, vasodilatory, and antiagregant effects. The main objective of this work was to investigate iloprost as an alternative agent versus hyperbaric oxygen (HBO) in the treatment of CRAO. Twenty-eight healthy Wistar albino male rats were randomly assigned into control (n = 7, sham operation), HBO (n = 7), iloprost (n = 7), and sham groups (n = 7). CRAO model was created through optic nerve exploration and ligation. Full-thickness retina (FTR), outer nuclear layer (ONL), inner nuclear layer (INL) and ganglion cell layer (GCL) thickness were measured on Hematoxylin/Eosin (H&E) stained retinal sections and immunohistochemical analysis including terminal deoxynucleotidyl transferase-mediated biotindeoxyuridine triphosphate nick-end labeling (TUNEL) assay was performed to determine the apoptotic index (AI). AI values of HBO (0.204 +/- 0.067) and iloprost (0.197 +/- 0.052) groups were significantly lower than sham (0.487 +/- 0.046) group (p < 0.001). Any significant difference was found between the HBO and iloprost groups in terms of AI (p = 0.514). A statistically significant increase in thickness of FTR, ONL, INL and GCL was detected in HBO, iloprost and sham groups compared to the control group (p = 0.002). FTR, ONL, INL and GCL thickness were significantly thinner in HBO and iloprost groups than in the sham group (p = 0.002). A significant lesser increase was observed in all the retinal layers thickness in iloprost group versus HBO group (p = 0.002) except for INL (p = 0.665). The study results demonstrated anti-edema, neuroprotective, and anti-apoptotic effects of iloprost quantitatively; thus, iloprost may be a beneficial alternative agent in the treatment of CRAO.en_US
dc.description.sponsorshipKocaeli University Scientific Research Projects Unit (KOU-BAP) [2012/002]en_US
dc.language.isoengen_US
dc.publisherSPRINGER-NEW YORKen_US
dc.relation.isversionof10.1007/s00417-016-3444-5en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRetinal artery occlusion, Hyperbaric oxygen therapy, Iloprost, Ischemia-reperfusion injuryen_US
dc.subjectISCHEMIA-REPERFUSION INJURY, CRITICAL LIMB ISCHEMIA, SPINAL-CORD ISCHEMIA, IN-VIVO EVALUATION, RABBIT MODEL, HYPERTENSION, DISEASE, ANALOGen_US
dc.titleComparison of hyperbaric oxygen versus iloprost treatment in an experimental rat central retinal artery occlusion modelen_US
dc.typearticleen_US
dc.relation.journalGRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGYen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0002-0501-1679en_US
dc.contributor.authorID0000-0002-2212-4448en_US
dc.contributor.authorID0000-0001-5463-2634en_US
dc.contributor.authorID0000-0002-8472-0261en_US
dc.contributor.authorID0000-0002-7660-6557en_US
dc.identifier.volume254en_US
dc.identifier.issue11en_US
dc.identifier.startpage2209en_US
dc.identifier.endpage2215en_US
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