Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/5082
Title: Selective nanosensor based on folic acid imprinted nanostructures
Authors: Kusat, Kevser
Sanli, Serdar
Timur, Suna
Akgol, Sinan
Ordu Üniversitesi
0000-0002-1981-7577
0000-0002-8528-1854
0000-0002-9048-287X
Keywords: Folic acid, nanostructures, MIP, nanobiosensors
GENERATION POLYMERIC NANOSPHERES, GRAPHENE OXIDE, ELECTROCHEMICAL DETECTION, GOLD NANOPARTICLES, URIC-ACID, ELECTRODE, SENSORS, FOLATE, CHEMILUMINESCENCE, PHARMACEUTICALS
Issue Date: 2022
Publisher: Tubitak Scientific & Technological Research Council Turkey-ANKARA
Citation: Kusat, K., Sanli, S., Timur, S., Akgöl, S. (2022). Selective nanosensor based on folic acid imprinted nanostructures. Turk. J. Chem., 46(4), 1210-1225. https://doi.org/10.55730/1300-0527.3428
Abstract: Folic acid, which provides the transfer of single carbon atoms in synthesis reactions and metabolic cycles in metabolism, is very important for metabolism. Folic acid also plays an important role in nucleotide synthesis and methylation reactions. There are many disorders caused by defective folic acid metabolism and lack of folic acid. Today, innovative, cost-effective methods are needed to develop folic acid determination methods. The main objective of this study is the development of surface-printed carbon electrodes (SPOE) modified with folic acid imprinted nanostructures (FA-Imp-poly(MPTS-rGO-co-NAT), which will be used for the first time for folic acid determination in commercially human blood serum. For this purpose, the synthesis of nanostructures has been carried out and characterized by FTIR, SEM-EDS, and AFM. Then, a new chemically modified nanosensor was fabricated for the determination of folic acid using folic acid imprinted nanostructures. Differential pulse voltammetry (DPV) and circular voltammetry (CV) methods were used as electrochemical methods in the FA-imprinted-nanosensor studies. Measurements in differential pulse voltammetry were performed at an application speed of 0.005 volts per second in the potential range of -0.4 to 0.6 volts. As a result of the circular voltammetric method, an idea about the surface was obtained with the voltammograms obtained. The detection limit (LOD) of the developed FA-imprinted-nanosensor was 7.54 ng/mL and the determination limit (LOQ) was 25.14 ng/mL. FA analytical (10 and 20 ng/mL) was added to commercial synthetic serum samples by the standard adding method and RSD values of 0.092% and 0.734% were found in the DPV technique and measurements respectively. This manuscript demonstrated a novel, simple, selective, and rapid FA-imprinted-nanosensor for determining the FA in the biological samples.
Description: WoS Categories: Chemistry, Multidisciplinary; Engineering, Chemical
Web of Science Index: Science Citation Index Expanded (SCI-EXPANDED)
Research Areas: Chemistry; Engineering
URI: http://dx.doi.org/10.55730/1300-0527.3428
https://www.webofscience.com/wos/woscc/full-record/WOS:000895319000023
http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/5082
ISSN: 1300-0527
Appears in Collections:Kimya

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