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DC Field | Value | Language |
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dc.contributor.author | Ahiskali, Ibrahim | - |
dc.contributor.author | Pinar, Can Lokman | - |
dc.contributor.author | Kiki, Murat | - |
dc.contributor.author | Cankaya, Murat | - |
dc.contributor.author | Kunak, Celaleddin Semih | - |
dc.contributor.author | Altuner, Durdu | - |
dc.date.accessioned | 2024-03-26T06:28:02Z | - |
dc.date.available | 2024-03-26T06:28:02Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Ahiskali, I., Pinar, CL., Kiki, M., Cankaya, M., Kunak, CS., Altuner, D. (2019). Effect of taxifolin on methanol-induced oxidative and inflammatory optic nerve damage in rats. Cutan. Ocul. Toxicol., 38(4), 384-389. https://doi.org/10.1080/15569527.2019.1637348 | en_US |
dc.identifier.issn | 1556-9527 | - |
dc.identifier.issn | 1556-9535 | - |
dc.identifier.uri | http://dx.doi.org/10.1080/15569527.2019.1637348 | - |
dc.identifier.uri | https://www.webofscience.com/wos/woscc/full-record/WOS:000476360300001 | - |
dc.identifier.uri | http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/5039 | - |
dc.description | WoS Categories: Ophthalmology; Toxicology | en_US |
dc.description | Web of Science Index: Science Citation Index Expanded (SCI-EXPANDED) | en_US |
dc.description | Research Areas: Ophthalmology; Toxicology | en_US |
dc.description.abstract | Purpose: Oxidative stress and inflammation have been demonstrated in the pathogenesis of methanol toxicity. Taxifolin has antioxidant and anti-inflammatory properties. In this study, we examined the protective effect of taxifolin against methanol-induced optic nerve toxicity. Materials and methods: Animals were divided into four groups (n = 6): healthy control group (HG), methotrexate (MTX) treated group, methotrexate + methanol treated group (MTX + M), and methotrexate + methanol + taxifolin treated group (MTX + M+T). MTX was administered to all groups except HG group 3 mg/kg via oral gavage for 7 d. After that 20% methanol was orally administered to the MTX + M and MTX + M+T group at a dose of 3 g/kg. After 4 h, taxifolin was orally administered to MTX + M+T group 50 mg/kg. Animals were sacrificed by high-dose thiopental anaesthesia, 8 h after taxifolin administration and biochemical studies were performed. Results: Malondialdehyde (MDA), total oxidant system, nuclear factor kappa B (NF-kappa B), and tumour necrosis factor-alpha levels were significantly higher in the optic nerve of MTX and MTX + M groups compared to HG group. Otherwise, total glutathione (tGSH) and total antioxidant system levels decreased in MTX and MTX + M groups according to the HG group. MDA, total oxidant system, NF-kappa B, and tumour necrosis factor-alpha levels were decreased in the MTX + M+T group and tGSH, and total antioxidant system levels increased in the MTX + M+T group according to the MTX + M group. Conclusions: These results indicate that taxifolin prevents oxidative and inflammatory optic nerve damage due to methanol exposure. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | TAYLOR & FRANCIS LTD-ABINGDON | en_US |
dc.relation.isversionof | 10.1080/15569527.2019.1637348 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Taxifolin, methanol, optic nerve, damage | en_US |
dc.subject | EXPRESSION, NEUROPATHY, APOPTOSIS, CELLS | en_US |
dc.title | Effect of taxifolin on methanol-induced oxidative and inflammatory optic nerve damage in rats | en_US |
dc.type | article | en_US |
dc.relation.journal | CUTANEOUS AND OCULAR TOXICOLOGY | en_US |
dc.contributor.department | Ordu Üniversitesi | en_US |
dc.identifier.volume | 38 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 384 | en_US |
dc.identifier.endpage | 389 | en_US |
Appears in Collections: | Dahili Tıp Bilimleri |
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