Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/4982
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dc.contributor.authorKarakus, Resul-
dc.contributor.authorKarakus, Esra-
dc.contributor.authorEmir, Suna-
dc.contributor.authorKacar, Ayper-
dc.contributor.authorOzyoruk, Derya-
dc.date.accessioned2024-03-26T06:21:32Z-
dc.date.available2024-03-26T06:21:32Z-
dc.date.issued2018-
dc.identifier.citationKarakus, R., Karakus, E., Emir, S., Kaçar, A., Özyörük, D. (2018). Insulin-like growth factor-1 receptor expression in pediatric tumors: a comparative immunohistochemical study. Turk. J. Med. Sci., 48(2), 419-423. https://doi.org/10.3906/sag-1801-233en_US
dc.identifier.issn1300-0144-
dc.identifier.issn1303-6165-
dc.identifier.urihttp://dx.doi.org/10.3906/sag-1801-233-
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000431261100032-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/4982-
dc.descriptionWoS Categories: Medicine, General & Internalen_US
dc.descriptionWeb of Science Index: Science Citation Index Expanded (SCI-EXPANDED)en_US
dc.descriptionResearch Areas: General & Internal Medicineen_US
dc.description.abstractBackground/aim: Insulin-like growth factor-1 receptor (IGF-1R) is a pivotal receptor tyrosine kinase involved in the cell cycle and malignant tumor transformation. It is differentially expressed in various types of tumors. We aimed to determine the expression of IGF-1R in different pediatric tumors and to shed light on possible new indications of anti-IGF-1R treatment approaches. Materials and methods: A total of 147 specimens were analyzed according to their expression of IGF-1R. Specimens included those from rhabdomyosarcomas, Wilms tumors, Ewing sarcoma/primitive neuroectodermal tumors, peripheral neuroblastic tumors, acute lymphoblastic lymphoma, Hodgkin lymphoma, Burkitt lymphoma, retinoblastoma, pleuropulmonary blastoma, Langerhans cell histiocytosis, endodermal sinus tumors (ESTs), and myeloid sarcoma. Analysis was performed on tissue sections by immunohistochemically staining for IGF-1R expression. Results: All six specimens of EST cases showed positivity for IGF-R1. Additionally, about 56% of the Hodgkin lymphoma, 80% of the rhabdomyosarcoma, and 70% of the Wilms tumor specimens showed positivity for IGF-R1 expression. Conclusion: All ESTs examined in our study expressed IGF-1R and to our knowledge this is the first report regarding ESTs and IGF-1R expression. IGF-1R could be included among confirmatory markers for ESTs and, from a therapeutic viewpoint, ESTs should also be examined for IGF-1R expression for beneficial regimens.en_US
dc.language.isoengen_US
dc.publisherTubitak Scientific & Technological Research Council Turkey-ANKARAen_US
dc.relation.isversionof10.3906/sag-1801-233en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInsulin-like growth factor-1 receptor, endodermal sinus tumor, neuroblastoma, Wilms tumor, rhabdomyosarcomaen_US
dc.subjectCELL LUNG-CANCER, MONOCLONAL-ANTIBODY, PROTEIN EXPRESSION, COPY NUMBER, RHABDOMYOSARCOMA, OSTEOSARCOMA, SARCOMAS, PATHWAY, IGF-1R, GENEen_US
dc.titleInsulin-like growth factor-1 receptor expression in pediatric tumors: a comparative immunohistochemical studyen_US
dc.typearticleen_US
dc.relation.journalTURKISH JOURNAL OF MEDICAL SCIENCESen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0003-2654-6119en_US
dc.contributor.authorID0000-0002-9615-6522en_US
dc.contributor.authorID0000-0003-2424-3763en_US
dc.identifier.volume48en_US
dc.identifier.issue2en_US
dc.identifier.startpage419en_US
dc.identifier.endpage423en_US
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