Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/4844
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dc.contributor.authorGuzel, Yunus-
dc.contributor.authorElmadag, Mehmet-
dc.contributor.authorUzer, Gokcer-
dc.contributor.authorYildiz, Fatih-
dc.contributor.authorBilsel, Kerem-
dc.contributor.authorTuncay, Ibrahim-
dc.date.accessioned2024-03-21T11:42:46Z-
dc.date.available2024-03-21T11:42:46Z-
dc.date.issued2017-
dc.identifier.citationGüzel, Y., Elmadag, M., Uzer, G., Yildiz, F., Bilsel, K., Tuncay, I. (2017). Cytotoxicity of a new antimicrobial coating for surgical screws: an in vivo study. Singap. Med. J., 58(1), 46-49. https://doi.org/10.11622/smedj.2016021en_US
dc.identifier.issn0037-5675-
dc.identifier.urihttp://dx.doi.org/10.11622/smedj.2016021-
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000396357300010-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/4844-
dc.descriptionWoS Categories: Medicine, General & Internalen_US
dc.descriptionWeb of Science Index: Science Citation Index Expanded (SCI-EXPANDED)en_US
dc.descriptionResearch Areas: General & Internal Medicineen_US
dc.description.abstractINTRODUCTION The risk of surgery-related infection is a persistent problem in orthopaedics and infections involving implants are particularly difficult to treat. This study explored the responses of bone and soft tissue to antimicrobial-coated screws. We investigated whether such screws, which have never been used to fix bony tissues, would result in a cytotoxic effect. We hypothesised that the coated screws would not be toxic to the bone and that the likelihood of infection would be reduced since bacteria are not able to grow on these screws. METHODS Titanium screws were inserted into the left supracondylar femoral regions of 16 rabbits. The screws were either uncoated (control group, n = 8) or coated with a polyvinylpyrrolidone-polyurethane interpolymer with tertiary amine functional groups (experimental group, n = 8). At Week 6, histological samples were obtained and examined. The presence of necrosis, fibrosis and inflammation in the bony tissue and the tissue surrounding the screws was recorded. RESULTS Live, cellular bone marrow was present in all the rabbits from the experimental group, but was replaced with connective tissue in four rabbits from the control group. Eight rabbits from the control group and two rabbits from the experimental group had necrosis in fatty bone marrow. Inflammation was observed in one rabbit from the experimental group and five rabbits from the control group. CONCLUSION Titanium surgical screws coated with polyvinylpyrrolidone-polyurethane interpolymer were associated with less necrosis than standard uncoated screws. The coated screws were also not associated with any cytotoxic side effect.en_US
dc.language.isoengen_US
dc.publisherSINGAPORE MEDICAL ASSOC-SINGAPOREen_US
dc.relation.isversionof10.11622/smedj.2016021en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectantimicrobial coating, coated screws, hydrophobic coating, implant infectionen_US
dc.subjectBIOFILM FORMATION, IMPLANT, SELENIUM, STAPHYLOCOCCI, PREVENTION, INFECTION, ADHERENCE, MODELen_US
dc.titleCytotoxicity of a new antimicrobial coating for surgical screws: an in vivo studyen_US
dc.typearticleen_US
dc.relation.journalSINGAPORE MEDICAL JOURNALen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0002-7402-756Xen_US
dc.contributor.authorID0000-0001-5778-692Xen_US
dc.identifier.volume58en_US
dc.identifier.issue1en_US
dc.identifier.startpage46en_US
dc.identifier.endpage49en_US
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