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Title: | The Role of AGT, AMPD1, HIF1α, IL-6 Gene Polymorphisms in the Athletes' Power Status: A Meta-Analysis |
Authors: | Ipekoglu, Gokhan Cetin, Tugba Apaydin, Necdet Calcali, Tugce Senel, Ebru Ordu Üniversitesi 0000-0002-8530-0031 0000-0002-8930-3205 |
Keywords: | sport genetics, gene, meta-analysis, athletic performance PRO582SER POLYMORPHISM, SKELETAL-MUSCLE, PERFORMANCE, ASSOCIATION |
Issue Date: | 2023 |
Publisher: | TERMEDIA PUBLISHING HOUSE LTD-POZNAN |
Citation: | Ipekoglu, G., Cetin, T., Apaydin, N., Calcali, T., Senel, E. (2023). The Role of AGT, AMPD1, HIF1α, IL-6 Gene Polymorphisms in the Athletes' Power Status: A Meta-Analysis. J. Hum. Kinet., 89(1), 77-87. https://doi.org/10.5114/jhk/169262 |
Abstract: | This meta-analysis was designed to investigate the relationship between genetic polymorphisms (AGT rs699, AMPD1 rs17602729, HIF1 alpha rs11549465, IL-6 rs1800795) and power athletes' status. Only case-control studies were included in the meta-analysis. A systematic search of the PubMed and Web of Science databases was performed to identify relevant studies and 23 studies met the inclusion criteria for the meta-analysis. The data from the included studies were pooled and analyzed using a random effects or fix effects model. The effect size was calculated as the odds ratio or a risk ratio with 95% confidence intervals. The results showed that certain genetic polymorphisms, AGT rs699 Thr allele, HIF1A rs11549465 Ser allele and AMPD1 rs17602729 C allele, were significantly more prevalent in power athletes (p < 0.05). When examining the genotype frequency distribution of AGT rs699 and AMPD1 rs17602729, significant differences were found in both the dominant and recessive models (p < 0.05). The results indicate that these gene polymorphisms play a role in power athlete status, however, new and more comprehensive studies are needed to confirm these results. |
Description: | WoS Categories: Sport Sciences Web of Science Index: Science Citation Index Expanded (SCI-EXPANDED) Research Areas: Sport Sciences |
URI: | http://dx.doi.org/10.5114/jhk/169262 https://www.webofscience.com/wos/woscc/full-record/WOS:001147030100007 http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/4831 |
ISSN: | 1640-5544 1899-7562 |
Appears in Collections: | Beden Eğitimi ve Spor Öğretmenliği |
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