Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/4784
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dc.contributor.authorCirakoglu, Abdullah-
dc.contributor.authorOnder, Sevda-
dc.contributor.authorHanci, Hatice-
dc.contributor.authorBenli, Erdal-
dc.contributor.authorYuce, Ahmet-
dc.contributor.authorArici, Yeliz Kasko-
dc.contributor.authorBas, Orhan-
dc.contributor.authorNalbant, Ismail-
dc.date.accessioned2024-03-20T13:44:27Z-
dc.date.available2024-03-20T13:44:27Z-
dc.date.issued2023-
dc.identifier.citationCirakoglu, A., Onder, S., Hanci, H., Benli, E., Yüce, A., Arici, YK., Bas, O., Nalbant, I. (2023). Does isotretinoin affect spermatogenesis in the long term? A rat model. Arch. Ital. Urol. Androl., 95(3). https://doi.org/10.4081/aiua.2023.11502en_US
dc.identifier.issn1124-3562-
dc.identifier.issn2282-4197-
dc.identifier.urihttp://dx.doi.org/10.4081/aiua.2023.11502-
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:001083764400001-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/4784-
dc.descriptionWoS Categories: Urology & Nephrologyen_US
dc.descriptionWeb of Science Index: Emerging Sources Citation Index (ESCI)en_US
dc.descriptionResearch Areas: Urology & Nephrologyen_US
dc.description.abstractObjectives: Spermatogenesis, in which cell regeneration continues, can be affected by environmental, chemical, psychological factors or various diseases. There is conflicting information in the literature about the effect of isotretinoin, which is widely used in acne treatment, on testes and spermatogenesis. Therefore, we planned a rat study to evaluate the long-term efficacy of oral isotretinoin on testicular tissues and spermatogenesis. Materials and methods: The Group 1 (n = 6) 7.5 mg/kg/day and the Group 2 (n = 6) received isotretinoin at a dose of 30 mg/kg/day dissolved in sunflower oil, the Sham Group (n = 6) received only sunflower oil by gavage, and the control group (n = 6) received standard feed and water for four weeks. After the 4(th) week, all animals were fed with standard feed and water and followed for the next four weeks. At the end of the 8th week, all animals were sacrificed under deep anesthesia. Seminiferous tubule diameters, epithelial thickness, apoptotic index, sperm number and motility recordedResults: Sperm count, motility, vitality, diameter of seminiferous tubule and germinal epithelium thickness were decreased and apoptotic index increased in the groups received isotretinoin. There was no significant difference between the groups in terms of testosterone levels.Conclusions: We consider that further comprehensive studies, including human clinical trials, should be conducted to examine the negative effects of isotretinoin on spermatogenesis in the long term especially when there is a need using isotretinoin in men for various reasons and to eliminate the contradictions in the literature in this regard.en_US
dc.language.isoengen_US
dc.publisherPAGEPRESS PUBL-PAVIAen_US
dc.relation.isversionof10.4081/aiua.2023.11502en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIsotretinoin, Rat, Spermatogenesis, Testisen_US
dc.subjectAPOPTOTIC INDEX, HORMONE-LEVELS, GERM-CELLS, ACITRETIN, PATHWAYS, EXPOSURE, ACNE, MENen_US
dc.titleDoes isotretinoin affect spermatogenesis in the long term? A rat modelen_US
dc.typearticleen_US
dc.relation.journalARCHIVIO ITALIANO DI UROLOGIA E ANDROLOGIAen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0003-2931-3927en_US
dc.contributor.authorID0000-0001-6820-0381en_US
dc.identifier.volume95en_US
dc.identifier.issue3en_US
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