Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/4749
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dc.contributor.authorErhan, Ertugrul-
dc.contributor.authorMammadov, Renad-
dc.contributor.authorBilgin, Asli O.-
dc.contributor.authorKunak, Celalettin S.-
dc.contributor.authorCankaya, Murat-
dc.contributor.authorCimen, Ferda K.-
dc.contributor.authorAltuner, Durdu-
dc.date.accessioned2024-03-19T06:54:08Z-
dc.date.available2024-03-19T06:54:08Z-
dc.date.issued2019-
dc.identifier.citationErhan, E., Mammadov, R., Bilgin, AO., Kunak, CS., Cankaya, M., Cimen, FK., Altuner, D. (2019). The Effect of Rutin on Cisplatin-Induced Oxidative Vestibular Nerve Damage in Rats. Lat. Am. J. Pharm., 38(6), 1259-1264en_US
dc.identifier.issn0326-2383-
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000472899800027-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/4749-
dc.descriptionWoS Categories: Pharmacology & Pharmacyen_US
dc.descriptionWeb of Science Index: Science Citation Index Expanded (SCI-EXPANDED)en_US
dc.descriptionResearch Areas: Pharmacology & Pharmacyen_US
dc.description.abstractOxidative stress is considered responsible for cisplatin autotoxicity. The aim of this study was to examine the protective effect of rutin on cisplatin-induced oxidative vestibular nerve damage in rats. Animals were divided into four groups (n = 6): healthy group (HG), 50 mg/kg rutin + cisplatin group (RG-50), 100 mg/kg rutin + cisplatin group (RG-100), and cisplatin group (CG). Rutin was administered orally for eight days, and 5 mg/kg cisplatin was injected intraperitoneally once every two days. Malondialdehyde, myeloperoxidase, and total glutathione levels were measured in serum and vestibular nerve tissue and examined histopathologically. Malondialdehyde and myeloperoxidase levels were lower in the serum and vestibular nerve tissue of RG-50 and RG-100 groups compared to the CG group; total glutathione was higher. Also, several histopathological changes were seen in the vestibular nerve tissue of the CG group. Rutin inhibited nerve tissue damage and may protect vestibular nerve tissue from cisplatin-induced oxidative damage.en_US
dc.language.isoengen_US
dc.publisherCOLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES-LA PLATAen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcisplatin, oxidative stress, rutin, vestibular nerveen_US
dc.subjectNEUROTROPHIC FACTOR, GANGLION NEURONS, STRESS, SURVIVAL, TISSUEen_US
dc.titleThe Effect of Rutin on Cisplatin-Induced Oxidative Vestibular Nerve Damage in Ratsen_US
dc.typearticleen_US
dc.relation.journalLATIN AMERICAN JOURNAL OF PHARMACYen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.identifier.volume38en_US
dc.identifier.issue6en_US
dc.identifier.startpage1259en_US
dc.identifier.endpage1264en_US
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