Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/4608
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dc.contributor.authorKhalil, Emced-
dc.contributor.authorOzcan, Sedat-
dc.date.accessioned2024-03-15T12:02:30Z-
dc.date.available2024-03-15T12:02:30Z-
dc.date.issued2020-
dc.identifier.citationKhalil, E., Ozcan, S. (2020). The safety and efficacy of pharmaco-mechanical thrombolysis in lower-extremity deep venous thrombosis. Cardiovasc. J. Afr., 31(6), 286-290. https://doi.org/10.5830/CVJA-2020-020en_US
dc.identifier.issn1995-1892-
dc.identifier.issn1680-0745-
dc.identifier.urihttp://dx.doi.org/10.5830/CVJA-2020-020-
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000599494800002-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/4608-
dc.descriptionWoS Categories: Cardiac & Cardiovascular Systemsen_US
dc.descriptionWeb of Science Index: Science Citation Index Expanded (SCI-EXPANDED)en_US
dc.descriptionResearch Areas: Cardiovascular System & Cardiologyen_US
dc.description.abstractObjectisve: The aim of this study was to investigate the impact of accelerated pharmaco-mechanical thrombolysis (PMT) with low-dose second-generation urokinase for the management of cases with lower-extremity deep venous thrombosis (DVT), and to compare its efficacy in subjects with acute and subacute DVT. Methods: Thirty-five patients with acute (< 15 days) or subacute (15 30 days) DVT who underwent PMT in a tertiary centre were enrolled in this single-arm, prospective study. Following the placement of a temporary Sena cava filter, urokinase (200 000 IU) was administered into the occlusion through a multi-hole catheter for 15 to 20 minutes. Control venography was performed to assess venous flow and the rate of acute recanalisation. Percutaneous balloon dilatation and stent placement were carried out in case of a residual iliac vein stenosis of > 50%. Any residual thrombi were suctioned with an aspiration catheter. The primary outcome measures of this study were the percentages of vessel potency and PTS in the third month after PMT. Results: Complete recanalisation was noted in 23 (66% patients, while two (6%) had poor recanalisation. The rate or minor complications was 14%. None of the subjects exper ienced major complications, such as intracranial haemorrhage or pulmonary embolism. No mortality was recorded during the three months of follow up. Control duplex ultrasonography in the third month revealed that the target vein was patent in all subjects. None of the subjects experienced PTS during follow up. In addition, the percentage of acute complete recanalisation was significantly higher in subjects with acute DVT compared to those with subacute DVT (95 vs 27%, p < 0.001). Conclusion: PMT with an accelerated regimen of low-dose urokinase provided excellent efficacy in the resolution of thrombus and prevented the development of PTS in the mid-term when used for the management of lower-extremity DVT.en_US
dc.language.isoengen_US
dc.publisherCLINICS CARDIVE PUBL PTY LTD-DURBANVILLEen_US
dc.relation.isversionof10.5830/CVJA-2020-020en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectdeep venous thrombosis, catheter-directed thrombolysis, urokinase, outcomesen_US
dc.subjectCATHETER-DIRECTED THROMBOLYSIS, TISSUE PLASMINOGEN-ACTIVATOR, VEIN THROMBOSIS, POSTTHROMBOTIC SYNDROME, RISK-FACTORS, MANAGEMENT, THERAPY, GUIDELINES, DIAGNOSIS, TRIALen_US
dc.titleThe safety and efficacy of pharmaco-mechanical thrombolysis in lower-extremity deep venous thrombosisen_US
dc.typearticleen_US
dc.relation.journalCARDIOVASCULAR JOURNAL OF AFRICAen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.identifier.volume31en_US
dc.identifier.issue6en_US
dc.identifier.startpage286en_US
dc.identifier.endpage290en_US
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