Cisplatin delivery from nickel supported Al2O3 powders: characterization with swelling and mutagenity tests

Abstract

Objective: In this study cisplatin release profile of Al2O3 powders with nickel phase supportion was investigated. Swelling property, mutagenity test and FTIR analysis were achieved for characterization of powders. Methods: Different formulations of nickel supported Al2O3 powders were synthesized for cisplatin release studies. Swelling ratio, Fourier transform infrared spectroscopy spectrum and Ames test were investigated for the characterization of Al2O3 and nickel supported Al2O3 powders. In vitro cisplatin release were studied in physiological saline solution and the amount of released cisplatin was determined with spectrophotometric analysis. Results: The powders showed a swelling degree between 46-86% and swelling ratio increased with increasing Ni phase. This behaviour has been explained on the basis of the softer character of nickel phase. And the results of Ames test indicate that all powder formulations are non-mutagenic. The release of cisplatin was studied as a function of time and all formulations showed non-Fickian diffusion with n value ranged between 0.55 and 0.69. Conclusion: The nickel supported Al2O3 formulations designed in this study, shows great promise as a cisplatin release material due to the favorable characteristics identified in these studies.