Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/4261
Title: Ferric Carboxymaltose-mediated Methemoglobinemia
Authors: Ozbilen, Muhammet
Savrun, Seyda Tuba
Aygun, Ali
Kaya, Yasemin
Ordu Üniversitesi
0000-0001-7360-8090
0000-0002-5190-1445
0000-0001-6052-7486
Keywords: Iron deficiency, anemia, intravenous iron, ferric carboxymaltose, side effect, methemoglobinemia
Issue Date: 2024
Publisher: BENTHAM SCIENCE PUBL-BUSUM
Citation: Özbilen, M., Savrun, ST., Aygün, A., Kaya, Y. (2024). Ferric Carboxymaltose-mediated Methemoglobinemia. Curr. Drug Saf., 19(1), 134-137. https://doi.org/10.2174/1574886318666230213111038
Abstract: Background Methemoglobinemia is a life-threatening disorder, with levels above 1 percent considered abnormal and typically resulting from drug or toxic substance exposure.Case Presentation In this study, we describe a case of a 43-year-old woman with a long-standing complaint of fatigue. Iron deficiency anemia was diagnosed based on the blood test findings of hemoglobin of 101 g/L, mean red blood cell volume of 75 fL, ferritin of 2.81 ug/L, transferrin saturation of 4.3 percent, and C-reactive protein of 0.6 mg/L. As a preferred treatment option, 1000 mg ferric carboxymaltose on two distinct days was preferred. After administering the first dose of the medication, we noticed incidentally that methemoglobin levels increased to 2.3%. When venous blood gas was repeated before and after administration of the second dose of the drug, methemoglobin levels were found to be 0.8% and 1.8%, respectively. There was no change in vital signs in both two dosages, and she only suffered a temporary sore throat. Her anemia improved with intravenous iron therapy, and she is currently being followed in our clinic.Conclusion No case or research reporting an increase in methemoglobin levels following oral and/or intravenous treatment to patients with iron deficiency anemia has been found in the literature. Therefore, this is the first contribution to the existing literature.
Description: WoS Categories: Pharmacology & Pharmacy
Web of Science Index: Emerging Sources Citation Index (ESCI)
Research Areas: Pharmacology & Pharmacy
URI: http://dx.doi.org/10.2174/1574886318666230213111038
https://www.webofscience.com/wos/woscc/full-record/WOS:001137324000022
http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/4261
ISSN: 1574-8863
2212-3911
Appears in Collections:Dahili Tıp Bilimleri

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