Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/4215
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dc.contributor.authorGulbay, Gonca-
dc.contributor.authorSavrun, Atakan-
dc.date.accessioned2024-03-15T08:28:10Z-
dc.date.available2024-03-15T08:28:10Z-
dc.date.issued2022-
dc.identifier.citationGülbay, G., Savrun, A. (2022). DNA damage and inflammation in COVID-19 cases. Cukurova Med. J., 47(3), 1073-1079. https://doi.org/10.17826/cumj.1102599en_US
dc.identifier.issn2602-3032-
dc.identifier.issn2602-3040-
dc.identifier.urihttp://dx.doi.org/10.17826/cumj.1102599-
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000889635700017-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/4215-
dc.descriptionWoS Categories: Medicine, General & Internalen_US
dc.descriptionWeb of Science Index: Emerging Sources Citation Index (ESCI)en_US
dc.descriptionResearch Areas: General & Internal Medicineen_US
dc.description.abstractPurpose: The aim of this study is to see oxidative DNA damage (8-OHdG), its relationship with inflammatory mediators (IL6 and TNFA), and its reflections on laboratory findings in patients who had COVID-19 infection at different intensities. Materials and Methods: Serum interleukin-6 (IL6), tumor necrosis factor-alpha (TNFA), and 8-hydroxy-2'deoxyguanosine (8-OHdG) levels were measured using kits based on the enzyme-linked immunosorbent assay (ELISA) principle. Results: In COVID-19 positive patients treated in intensive care 8-OHdG marker level is at the highest level and statistically significant. In patients receiving inpatient treatment in the hospitalized, the 8-OHdG marker level is higher than the control and outpatient groups. IL6 values were at the highest level in the patient group treated in the intensive care unit and were higher than the outpatient and control groups. There was no statistically significant difference between the control and patient groups in terms of TNFA values. Neutrophil-to-lymphocyte ratio (NLR) was lower in the control group than in all patient groups. C-reactive protein (CRP) is higher in hospitalized patients than in the control group. Lactate dehydrogenase (LDH) was found to be statistically significantly higher in hospitalized patients than outpatients. Conclusion: As the severity of COVID-19 increases, serum 8-OHdG and IL6 levels also increase. These parameters can guide the diagnosis of COVID-19 patients in the early stages of the disease course.en_US
dc.description.sponsorshipOrdu University Scientific Research Projects Coordination Unit Ordu, Turkey [A2119]en_US
dc.language.isoengen_US
dc.publisherCUKUROVA UNIV, FAC MEDICINE-ADANAen_US
dc.relation.isversionof10.17826/cumj.1102599en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19, DNA damage, Interleukin-6, Tumor necrosis factor-alpha, 8-hydroxy-2'deoxyguanosineen_US
dc.subjectCYTOKINE STORMen_US
dc.titleDNA damage and inflammation in COVID-19 casesen_US
dc.typearticleen_US
dc.relation.journalCUKUROVA MEDICAL JOURNALen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.identifier.volume47en_US
dc.identifier.issue3en_US
dc.identifier.startpage1073en_US
dc.identifier.endpage1079en_US
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