Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3684
Title: The effect of ellagic acid on the repair process of periodontal defects related to experimental periodontitis in rats
Authors: Dede, Figen Ongoz
Dogan, Seyma Bozkurt
Balli, Umut
Durmuslar, Mustafa Cenk
Avci, Bahattin
Gulle, Kanat
Ferah, Meryem Akpolat
Ordu Üniversitesi
Keywords: GINGIVAL OXIDATIVE STRESS; VITAMIN-C; INFLAMMATION; POLYPHENOLS; EXTRACT; DISEASE; ALPHA; SEED
Ellagic acid; Periodontitis; Periodontal repair; Cytokines; Antioxidant; Alveolar bone defect
Issue Date: 2021
Publisher: UNIV SAO PAULO FAC ODONTOLOGIA BAURU BAURU-SP
Citation: Dede, FO., Dogan, SB., Balli, U., Durmuslar, MC., Avci, B., Gulle, K., Ferah, MA. (2021). The effect of ellagic acid on the repair process of periodontal defects related to experimental periodontitis in rats. Journal of Applied Oral Science, 29, -.Doi:10.1590/1678-7757-2021-0160
Abstract: Objective: This study aims to evaluate the effect of ellagic acid (EA) by measuring the levels of alveolar bone resorption and inflammatory and oxidative stress markers in the periodontal tissues and serum on the periodontal repair process related to experimental periodontitis in rats. Methodology: Forty Wistar rats were divided into four study groups as follows: Group 1=healthy control (n=10); Group 2=EA control (15 mg/kg)(n=10); Group 3=periodontitis (n=10); Group 4=periodontitis+EA (15 mg/kg) (n=10). The periodontitis model was established by ligating bilateral mandibular first molars for 14 days. Then, rats were given normal saline or EA for another 14 days by gavage administration. Serum and gingiva myeloperoxidase (MPO) activity, 8-hydroxydeoxyguanosine(8-OHdG), and glutathione (GSH) levels were analyzed by ELISA. Immunohistochemical analysis was used to detect Interleukin (IL)-6, IL-10, and tumor necrosis factor-alpha (TNF-alpha) immunoreactivities in the periodontal tissues. Alveolar bone loss (ABL) and attachment loss (AL) was evaluated by histomorphometry analysis. Results: ABL and AL were statistically higher in group 3 than in groups 1, 2 and 4 and in group 4 than in groups 1 and 2 (p<0.05). MPO activities in gingival tissue and serum were significantly increased in group 3 compared to groups 1 and 2 (p<0.05). Significantly higher serum GSH levels, lower gingiva, and serum 8-OHdG levels, and MPO activity were observed in group 4 compared to group 3 (p<0.05). Rats with periodontitis (group 3) expressed significantly higher immunoreactivities of IL-6 and TNF-alpha and lower IL-10 immunoreactivity compared to those other groups (p<0.05). IL-6 and TNF-alpha immunoreactivities significantly decreased and IL-10 immunoreactivity increased in group 4 after the use of EA compared to group 3 (p<0.001). Conclusions: Our findings showed that EA provides significant improvements on gingival oxidative stress and inflammatory markers and alveolar bone resorption in the repair process associated with experimental periodontitis. Therefore, EA may have a therapeutic potential on periodontitis.
Description: WoS Categories : Dentistry, Oral Surgery & Medicine Web of Science Index : Science Citation Index Expanded (SCI-EXPANDED) Research Areas : Dentistry, Oral Surgery & Medicine Open Access Designations : gold, Green Published
URI: http://dx.doi.org/10.1590/1678-7757-2021-0160
https://www.webofscience.com/wos/woscc/full-record/WOS:000703485700001
https://pubmed.ncbi.nlm.nih.gov/34586188
http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3684
ISBN: 1678-7757
1678-7765
Appears in Collections:Periodontoloji

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