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DC Field | Value | Language |
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dc.contributor.author | Dogan, Seyma Bozkurt | - |
dc.contributor.author | Dede, Figen Ongoz | - |
dc.contributor.author | Balli, Umut | - |
dc.contributor.author | Sertoglu, Erdim | - |
dc.date.accessioned | 2023-01-06T12:11:14Z | - |
dc.date.available | 2023-01-06T12:11:14Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Dogan, SB., Dede, FO., Balli, U., Sertoglu, E. (2021). Emerging roles of Interleukin-34 together with receptor activator of nuclear factor-kB ligand and osteoprotegerin levels in periodontal disease. Cytokine, 144, -.Doi:10.1016/j.cyto.2021.155584 | en_US |
dc.identifier.isbn | 1043-4666 | - |
dc.identifier.isbn | 1096-0023 | - |
dc.identifier.uri | http://dx.doi.org/10.1016/j.cyto.2021.155584 | - |
dc.identifier.uri | https://www.webofscience.com/wos/woscc/full-record/WOS:000657696400010 | - |
dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/34034144 | - |
dc.identifier.uri | http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3646 | - |
dc.description | WoS Categories : Biochemistry & Molecular Biology; Cell Biology; Immunology Web of Science Index : Science Citation Index Expanded (SCI-EXPANDED) Research Areas : Biochemistry & Molecular Biology; Cell Biology; Immunology | en_US |
dc.description.abstract | Objective: The dependence between gingival crevicular fluid (GCF) of Interleukin-34 (IL-34) level and Receptor activator of nuclear factor -kB ligand/ osteoprotegerin (RANKL/OPG) ratio in the severity of periodontitis might reveal an unknown pathway of diseases with bone destruction. There is no study about the evaluation of IL-34 levels together with GCF RANKL and OPG levels in periodontitis patients before and after non-surgical periodontal treatment (NSPT). The objectives of this research were to investigate changes in the levels and relative ratios of IL-34, OPG, and RANKL in the GCF of patients with periodontitis before and after NSPT. Materials and Methods: 20 healthy participants (CTRL), 20 patients with stage 3-grade B periodontitis and 20 with stage 3-grade C periodontitis were recruited. GCF and clinical periodontal recordings were investigated at the baseline and 6 weeks after NSPT. Enzyme-linked immunosorbent assay (ELISA) were used for quantifying of GCF IL-34, RANKL and OPG levels and their relative ratios were calculated. Results: Greater values for GCF IL-34 and RANKL levels were found in the both of periodontitis groups than in CTRL group at baseline, whereas GCF OPG levels were statistically lower at baseline (P < 0.05). GCF IL-34 and RANKL levels decreased in the 6th week after NSPT in the both periodontitis groups, while the concentration OPG levels statistically increased (P < 0.05). Significantly positive correlations among the IL-34 with RANKL, sampled-site clinical attachment level (CAL), and gingival index (GI), whereas negative correlation with OPG were reported (P < 0.05). Conclusions: GCF IL-34 levels was high in patients with periodontitis and decreased after NSPT and its levels showed positive correlations with RANKL/OPG ratio levels CAL and GI. Determining of IL-34 levels together with RANKL/OPG ratio in GCF may therefore be valuable in detecting high risk individuals with periodontitis patients. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD LONDON | en_US |
dc.relation.isversionof | 10.1016/j.cyto.2021.155584 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | GINGIVAL CREVICULAR FLUID; KAPPA-B LIGAND; PERI-IMPLANT DISEASES; STIMULATING FACTOR-I; AGGRESSIVE PERIODONTITIS; MESSENGER-RNA; RANKL; CLASSIFICATION; OPG; SALIVARY | en_US |
dc.subject | Periodontitis; Gingival crevicular fluid; Interleukin-34; RANKL; OPG | en_US |
dc.title | Emerging roles of Interleukin-34 together with receptor activator of nuclear factor-kB ligand and osteoprotegerin levels in periodontal disease | en_US |
dc.type | article | en_US |
dc.relation.journal | CYTOKINE | en_US |
dc.contributor.department | Ordu Üniversitesi | en_US |
dc.identifier.volume | 144 | en_US |
Appears in Collections: | Periodontoloji |
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