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Title: | Antimicrobial activity, inhibition of biofilm formation, and molecular docking study of novel Ag-NHC complexes |
Authors: | Sahin, Neslihan Ustun, Elvan Tutar, Ugur Celik, Cem Gurbuz, Nevin Ozdemir, Ismail Ordu Üniversitesi 0000-0003-3201-3597 |
Keywords: | HETEROCYCLIC CARBENE COMPLEXES; THEORETICAL-ANALYSIS; MALATE SYNTHASE; MECHANISM; AG(I) N-heterocyclic carbene; Benzimidazolium salt; Antimicrobial activity; Biofilm activity; Molecular docking |
Issue Date: | 2021 |
Publisher: | ELSEVIER SCIENCE SA LAUSANNE |
Citation: | Sahin, N., Ustun, E., Tutar, U., Celik, C., Gurbuz, N., Ozdemir, I. (2021). Antimicrobial activity, inhibition of biofilm formation, and molecular docking study of novel Ag-NHC complexes. Journal of Organometallic Chemistry, 954, -.Doi:10.1016/j.jorganchem.2021.122082 |
Abstract: | In this study, we reported the synthesis of a new series of Silver(I)-N-heterocyclic carbene complexes which were obtained from the corresponding new N-heterocyclic carbene (NHC) precursors. All new compounds were characterized by elemental analysis, FT-IR, LC-MS, H-1 NMR, and C-13{H-1} NMR spectroscopy. These new N-heterocyclic carbene precursors and Ag(I)-NHC complexes were evaluated for their antibacterial, antifungal, and antibiofilm activities. The biological activities of synthesized products were compared with standard drugs. All compounds have moderate antibacterial and antibiofilm activities. In particular, while compound 2a was found to be the best inhibitor of E. coli biofilms, while compound 2d inhibited C. albicans biofilm at the highest rate. All the compounds were also analyzed by molecular docking methods with the certain target molecules. (C) 2021 Elsevier B.V. All rights reserved. |
Description: | WoS Categories : Chemistry, Inorganic & Nuclear; Chemistry, Organic Web of Science Index : Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC) Research Areas : Chemistry |
URI: | http://dx.doi.org/10.1016/j.jorganchem.2021.122082 https://www.webofscience.com/wos/woscc/full-record/WOS:000744259200001 http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3628 |
ISBN: | 0022-328X 1872-8561 |
Appears in Collections: | Kimya |
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