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DC Field | Value | Language |
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dc.contributor.author | Sekeroglu, Vedat Atli | - |
dc.contributor.author | Sekeroglu, Vedat | - |
dc.contributor.author | Isik, Sevil | - |
dc.contributor.author | Aydin, Birsen | - |
dc.date.accessioned | 2023-01-06T11:40:24Z | - |
dc.date.available | 2023-01-06T11:40:24Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Sekeroglu, VA., Sekeroglu, V., Isik, S., Aydin, B. (2021). Trimetazidine alone or in combination with gemcitabine and/or abraxane decreased cell viability, migration and ATP levels and induced apoptosis of human pancreatic cells. Clinics and Research in Hepatology and Gastroenterology, 45(6), -.Doi:10.1016/j.clinre.2021.101632 | en_US |
dc.identifier.isbn | 2210-7401 | - |
dc.identifier.isbn | 2210-741X | - |
dc.identifier.uri | http://dx.doi.org/10.1016/j.clinre.2021.101632 | - |
dc.identifier.uri | https://www.webofscience.com/wos/woscc/full-record/WOS:000704808300029 | - |
dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/33662778 | - |
dc.identifier.uri | http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3556 | - |
dc.description | WoS Categories : Gastroenterology & Hepatology Web of Science Index : Science Citation Index Expanded (SCI-EXPANDED) Research Areas : Gastroenterology & Hepatology | en_US |
dc.description.abstract | Background: Trimetazidine (TMZ) is an anti-ischemic agent that can inhibit the fatty acid oxi-dation. It has been stated that inhibition of fatty acid oxidation may be an acceptable approach to cancer treatment. Methods: We examined the effects of TMZ alone or together with abraxane (ABX) and/or gemcitabine (GEM) on cell viability, apoptosis, adhesion, migration and ATP levels of human pancreatic cancer cell line PANC-1. Results: TMZ significantly reduced the cell viability at higher concentrations. Lower cell via-bility values were found in cells co-treated with TMZ + GEM, TMZ + ABX and GEM + ABX. The combined treatment of TMZ with ABX and/or GEM significantly increased the apoptosis rates. The highest percentages of apoptosis were found in TMZ + ABX or TMZ + ABX + GEM treatments. TMZ alone or together with ABX and/or GEM significantly reduced the ATP levels. The lowest migration rates were also found at TMZ + ABX and TMZ + ABX + GEM treatments. Conclusions: Our study is the first study to indicate that TMZ can induce cytotoxicity and apop-tosis and reduce migration and ATP levels, especially in cells co-treated with ABX and/or GEM. A combination strategy based on inhibition of fatty acid oxidation and anticancer drugs may be more effective in the treatment of pancreatic cancers. (c) 2021 Elsevier Masson SAS. All rights reserved. | en_US |
dc.description.sponsorship | Funding Orgs : Scientific Research Funding of Ordu University (Turkey) [AR-1830] Funding Name Preferred : Scientific Research Funding of Ordu University (Turkey) Funding Text : This work is financially supported by the Scientific Research Funding of Ordu University (Turkey) (Project No: AR-1830). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | ELSEVIER MASSON, CORP OFF PARIS | en_US |
dc.relation.isversionof | 10.1016/j.clinre.2021.101632 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | ISCHEMIA-REPERFUSION; CANCER; SURVIVAL; HIF-1-ALPHA; PACLITAXEL; INHIBITION; GROWTH | en_US |
dc.subject | Trimetazidine; Apoptosis; Migration; Adhesion; Pancreatic carcinoma | en_US |
dc.title | Trimetazidine alone or in combination with gemcitabine and/or abraxane decreased cell viability, migration and ATP levels and induced apoptosis of human pancreatic cells | en_US |
dc.type | article | en_US |
dc.relation.journal | CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY | en_US |
dc.contributor.department | Ordu Üniversitesi | en_US |
dc.contributor.authorID | 0000-0002-3552-3819 | en_US |
dc.identifier.volume | 45 | en_US |
dc.identifier.issue | 6 | en_US |
Appears in Collections: | Moleküler Biyoloji ve Genetik Bölümü |
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