Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3483
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dc.contributor.authorCelen, Selman-
dc.contributor.authorDede, Figen Ongoz-
dc.contributor.authorAvsar, Candeger-
dc.date.accessioned2023-01-06T11:09:51Z-
dc.date.available2023-01-06T11:09:51Z-
dc.date.issued2022-
dc.identifier.citationCelen, S., Dede, FO., Avsar, C. (2022). Role of Inhibitor SMADs in Stage 3 Grade B periodontitis before and after periodontal treatment. Journal of Periodontal Research, 57(1), 41-51.Doi:10.1111/jre.12935en_US
dc.identifier.isbn0022-3484-
dc.identifier.isbn1600-0765-
dc.identifier.urihttp://dx.doi.org/10.1111/jre.12935-
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000700491200001-
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/34581437-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3483-
dc.descriptionWoS Categories : Dentistry, Oral Surgery & Medicine Web of Science Index : Science Citation Index Expanded (SCI-EXPANDED) Research Areas : Dentistry, Oral Surgery & Medicineen_US
dc.description.abstractObjective This study aimed to examine the levels of transforming growth factor-beta (TGF-beta) and inhibitory-Smads (I-Smads) in saliva and gingival crevicular fluid (GCF) in patients with Stage 3 Grade B periodontitis before and after non-surgical periodontal treatment. Background Recently, it has been stated that Smads play an active role in all conditions where TGF-beta is involved, including periodontal inflammation. Methods Twenty healthy participants (control) and 20 patients with Stage 3, Grade B periodontitis were recruited. GCF and saliva samples and clinical periodontal recordings were investigated at the baseline and 1 month after treatment. TGF-beta and I-Smads (Smads 6 and 7) were determined by ELISA. Results Salivary Smad6 and Smad7 levels were significantly lower in the periodontitis group than healthy controls (p < .05), while there was no difference in salivary TGF-beta levels between groups at baseline (p > .05). The total amounts and concentrations of GCF TGF-beta, Smad6, and Smad7 were significantly lower in the periodontitis group than healthy controls at baseline (p < .05), and then decreased in concentration levels with treatment (p < .001). Positive correlations were found between total amounts and concentrations of GCF TGF-beta, Smad6, and Smad7 (p < .05). Conclusion Our findings revealed that Smad6 and Smad7 in GCF and saliva decreased in periodontitis and then increased after periodontal treatment. Our study suggests that I-Smads act in parallel with TGF-beta in periodontal inflammation and may have a role in the development of periodontitis.en_US
dc.description.sponsorshipFunding Orgs : Scientific Research Fund of Ordu University, Ordu, Turkey [B-1921] Funding Name Preferred : Scientific Research Fund of Ordu University, Ordu, Turkey Funding Text : Scientific Research Fund of Ordu University, Ordu, Turkey, Grant/Award Number: B-1921en_US
dc.language.isoengen_US
dc.publisherWILEY HOBOKENen_US
dc.relation.isversionof10.1111/jre.12935en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGINGIVAL CREVICULAR FLUID; GROWTH-FACTORS; OVEREXPRESSION; INFLAMMATION; MECHANISMS; LEVEL; BMP; CLASSIFICATION; PROLIFERATION; TGF-BETA-1en_US
dc.subjectgingival crevicular fluid; non-surgical periodontal treatment; periodontitis; saliva; Smad6; Smad7; TGF-betaen_US
dc.titleRole of Inhibitor SMADs in Stage 3 Grade B periodontitis before and after periodontal treatmenten_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF PERIODONTAL RESEARCHen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0003-2983-8758en_US
dc.identifier.volume57en_US
dc.identifier.issue1en_US
dc.identifier.startpage41en_US
dc.identifier.endpage51en_US
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