Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3482
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dc.contributor.authorKelebekli, Latif-
dc.contributor.authorYilmaz, Fatma Zehra-
dc.contributor.authorCol Ayvaz, Melek-
dc.contributor.authorSahin, Ertan-
dc.date.accessioned2023-01-06T11:09:42Z-
dc.date.available2023-01-06T11:09:42Z-
dc.date.issued2022-
dc.identifier.citationKelebekli, L., Yilmaz, FZ., Ayvaz, MC., Sahin, E. (2022). Synthesis and biological effects evaluation of benzoconduritols C and D from oxabenzonorbornadiene. Journal of the Iranian Chemical Society, 19(5), 1899-1912.Doi:10.1007/s13738-021-02428-0en_US
dc.identifier.isbn1735-207X-
dc.identifier.isbn1735-2428-
dc.identifier.urihttp://dx.doi.org/10.1007/s13738-021-02428-0-
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000709665000001-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3482-
dc.descriptionWoS Categories : Chemistry, Multidisciplinary Web of Science Index : Science Citation Index Expanded (SCI-EXPANDED) Research Areas : Chemistryen_US
dc.description.abstractThe effective synthesis of benzoconduritols C and D is reported. Oxidation of oxabenzonorbornadiene followed by acetylation with Ac2O/pyridine or AcCl/CH2Cl2 gave the corresponding exo-diacetate compound stereoselectively. Acid-catalyzed ring opening of the bridged ether bond (the 1,4-anhydo bond) with Ac2O in the oxabenzonorbornadiene system to produce benzoconduritol tetraacetates followed by ammonolysis furnished the desired benzoconduritols C and D, respectively. The novel benzoconduritols (9, 10, 15, 16, and 17) were evaluated for the first time in terms of their potential antioxidant, anti-inflammatory, and enzyme inhibition activities. Most of the complexes exhibited moderate activity. Especially 15 (IC50 = 0.374 mM) and 10 (IC50 = 0.450 mM) have better anti-inflammatory effect when compared to ibuprofen (IC50 = 0.437 mM). Furthermore, the benzoconduritol C 9 has better alpha-glucosidase inhibition potential with the IC50 value of 0.437 mM than acarbose (IC50 = 0.445 mM). The results of this study point out that most of these molecules have the potential to provide an alternative for the clinical control of inflammation and diabetes due to their anti-inflammatory and anti-glucosidase activities. Graphic abstracten_US
dc.description.sponsorshipFunding Orgs : Ordu University Scientific Research Projects Coordination Unit (ODU/BAP) [B-1908] Funding Name Preferred : Ordu University Scientific Research Projects Coordination Unit (ODU/BAP) Funding Text : The authors are indebted to Ordu University Scientific Research Projects Coordination Unit (ODU/BAP, Grant No: B-1908) for financial support of this work.en_US
dc.language.isoengen_US
dc.publisherSPRINGER NEW YORKen_US
dc.relation.isversionof10.1007/s13738-021-02428-0en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSTEREOSPECIFIC SYNTHESIS; MUSHROOM TYROSINASE; CONDURITOL; DERIVATIVES; STRATEGY; GLYCOSYLATION; GLUCOSIDASE; INHIBITORS; GLYCOSIDES; HYDROLYSISen_US
dc.subjectAcetylcholinesterase; alpha-Glucosidase; Anti-inflamatuar; Benzoconduritols; Ring opening of bridged etheren_US
dc.titleSynthesis and biological effects evaluation of benzoconduritols C and D from oxabenzonorbornadieneen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF THE IRANIAN CHEMICAL SOCIETYen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0002-6242-2589en_US
dc.identifier.volume19en_US
dc.identifier.issue5en_US
dc.identifier.startpage1899en_US
dc.identifier.endpage1912en_US
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