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DC Field | Value | Language |
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dc.contributor.author | Sahin, Ebrar Nur | - |
dc.contributor.author | Karanfil, Abdullah | - |
dc.contributor.author | Ayvaz, Melek col | - |
dc.contributor.author | Sahin, Ertan | - |
dc.contributor.author | Kelebekli, Latif | - |
dc.date.accessioned | 2023-01-06T11:03:55Z | - |
dc.date.available | 2023-01-06T11:03:55Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Sahin, EN., Karanfil, A., Ayvaz, MC., Sahin, E., Kelebekli, L. (2022). Structural analysis of halogenated bicyclo[4.2.0] inositols, biological activities and molecular docking studies. Journal of Molecular Structure, 1248, -.Doi:10.1016/j.molstruc.2021.131357 | en_US |
dc.identifier.isbn | 0022-2860 | - |
dc.identifier.isbn | 1872-8014 | - |
dc.identifier.uri | http://dx.doi.org/10.1016/j.molstruc.2021.131357 | - |
dc.identifier.uri | https://www.webofscience.com/wos/woscc/full-record/WOS:000703681000001 | - |
dc.identifier.uri | http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3449 | - |
dc.description | WoS Categories : Chemistry, Physical Web of Science Index : Science Citation Index Expanded (SCI-EXPANDED) Research Areas : Chemistry | en_US |
dc.description.abstract | The halogenated bicyclo[4.2.0] inositols (chiro-, scyllo- and muco-inositol derivatives) and a cyclic sulfate were obtained using cyclooctatetraene (COT). One of these structures (tetrol 12 ) was resolved by X-ray diffraction and the stereochemistry of the structure was determined. The antioxidant, anti-inflammatory and enzyme inhibition potentials of the six compounds were investigated. While all compounds show moderate antioxidant activity, they have a highly effective anti-inflammatory effect when compared to the standard drug ibuprofen. In addition, most of the compounds have considerable inhibitory potential on cholinesterase enzymes, although much more pronounced on alpha-glucosidase. Also, we performed molecular docking studies on AChE and BuChE enzymes for therapeutic alzheimer's patients and alpha-glocosidase enzymes for type-2 diabetes patients for enzyme inhibition. Cyclic Sulfate 10 is more active against AChE, BuChE and alpha-glocosidase, with calculated binding energies of -8.22,-7.58, and -6.59 kcal mol(-1) respectively as compared to galantamine and acarbose standard for which the binding energy was calculated to be -8.14 (AChE),-7.53 (BuChE) and -4.84 (alpha-glocosidase) kcal mol(-1), respectively. (C) 2021 Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | Funding Orgs : Ordu University Scientific Research Projects Coordination Unit (ODU/BAP) [AR-1659]; Ataturk University Scientific Research Projects Coordination Unit (BAP) [2013/77] Funding Name Preferred : Ordu University Scientific Research Projects Coordination Unit (ODU/BAP); Ataturk University Scientific Research Projects Coordination Unit (BAP)(Ataturk University) Funding Text : The authors are indebted to Ordu University Scientific Research Projects Coordination Unit (ODU/BAP, Grant No: AR-1659) and Ataturk University Scientific Research Projects Coordination Unit (BAP, Project No. 2013/77) for financial support of this work. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | ELSEVIER AMSTERDAM | en_US |
dc.relation.isversionof | 10.1016/j.molstruc.2021.131357 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | PERIPHERAL ANIONIC SITE; STEREOSPECIFIC SYNTHESIS; ANTIOXIDANT; ACETYLCHOLINESTERASE; STRATEGY; DERIVATIVES; INHIBITORS; DISCOVERY; ORAC; MONO | en_US |
dc.subject | Halogenated cyclitols; Antioxidant; Anti-inflammatuar; Anti-cholinesterase; Molecular docking | en_US |
dc.title | Structural analysis of halogenated bicyclo[4.2.0] inositols, biological activities and molecular docking studies | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF MOLECULAR STRUCTURE | en_US |
dc.contributor.department | Ordu Üniversitesi | en_US |
dc.contributor.authorID | 0000-0003-2948-4216 | en_US |
dc.identifier.volume | 1248 | en_US |
Appears in Collections: | Kimya |
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