Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3360
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dc.contributor.authorBagdatli, Emine-
dc.contributor.authorCil, Elif-
dc.date.accessioned2023-01-06T10:39:26Z-
dc.date.available2023-01-06T10:39:26Z-
dc.date.issued2022-
dc.identifier.citationBagdatli, E., Cil, E. (2022). Sulfa drugs-based Norbornenyl imides and reductive Heck reactions: Synthesis and antimicrobial screening. Journal of Heterocyclic Chemistry, 59(2), 264-274.Doi:10.1002/jhet.4380en_US
dc.identifier.isbn0022-152X-
dc.identifier.isbn1943-5193-
dc.identifier.urihttp://dx.doi.org/10.1002/jhet.4380-
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000710220300001-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3360-
dc.descriptionWoS Categories : Chemistry, Organic Web of Science Index : Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC) Research Areas : Chemistryen_US
dc.description.abstractIn the field of our research interest, we designed new sulfa drugs-substituted norbornyl imides as prospective bioactive scaffolds by the reaction of endo-endic anhydride with sulfa drugs followed by reductive Heck reactions of these products. Norbornenyl imides, as starting compounds, and their Heck products were achieved in good yields. Molecular characterization and stereochemistry of the compounds were investigated using Fourier transform infrared, liquid chromatography time-of-flight mass spectrometry, proton nuclear magnetic resonance, carbon 13 attached proton test, H-H correlation spevtroscopy, and nuclear overhauser enhancement spectroscopy experiments. The Heck products of norbornenyl imides showed exo-selectivity. All eight novel synthesized compounds, including two sulfa drugs-based norbornenyl imides and six exo-5-aryl- substituted norbornyl imides, as well as standard sulfonamides, were evaluated for antimicrobial activity against nine microorganisms consisting of Gram-negative bacteria, Gram-positive nonactinobacteria, actinobacteria, and yeast. The most active compound was 3a against actinobacteria. The efficacy of 2 and its derivatives against the studied strains were weaker than 3 and its derivatives, but all the studied samples exhibited antifungal potency.en_US
dc.description.sponsorshipFunding Orgs : Ordu University, Scientific Research Projects Coordination Department (ODU-BAP) [A-1809] Funding Name Preferred : Ordu University, Scientific Research Projects Coordination Department (ODU-BAP) Funding Text : Ordu University, Scientific Research Projects Coordination Department (ODU-BAP), Grant/Award Number: A-1809en_US
dc.language.isoengen_US
dc.publisherWILEY HOBOKENen_US
dc.relation.isversionof10.1002/jhet.4380en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectD-2 RECEPTOR ANTAGONISTS; BIOLOGICAL-ACTIVITY; SPECIES-DIVERSITY; DERIVATIVES; EPIBATIDINE; ANALOGS; POTENTen_US
dc.titleSulfa drugs-based Norbornenyl imides and reductive Heck reactions: Synthesis and antimicrobial screeningen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF HETEROCYCLIC CHEMISTRYen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0003-1420-8729en_US
dc.identifier.volume59en_US
dc.identifier.issue2en_US
dc.identifier.startpage264en_US
dc.identifier.endpage274en_US
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