Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3245
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dc.contributor.authorKokturk, Sibel-
dc.contributor.authorYardimoglu, Melda-
dc.contributor.authorCelikozlu, Saadet D.-
dc.contributor.authorDolanbay, Elif Gelenli-
dc.contributor.authorCimbiz, Ali-
dc.date.accessioned2022-09-09T10:36:41Z-
dc.date.available2022-09-09T10:36:41Z-
dc.date.issued2013-
dc.identifier.urihttp://doi.org/10.3892/etm.2013.1123-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3245-
dc.description.abstractThe expansion of mobile phone technology has raised concerns regarding the effect of 900-MHz electromagnetic field (EMF) exposure on the central nervous system. At present, the developing human brain is regularly exposed to mobile telephones, pre- and postnatally. Several studies have demonstrated the acute effects of EMF exposure during pre- or postnatal periods; however, the chronic effects of EMF exposure are less understood. Thus, the aim of the present study was to determine the chronic effects of EMF on the pre- and postnatal rat cerebellum. The control group was maintained in the same conditions as the experimental groups, without the exposure to EMF. In the EMF1 group, the rats were exposed to EMF during pre- and postnatal periods (until postnatal day 80). In the EMF2 group, the rats were also exposed to EMF pre- and postnatally; in addition, however, they were provided with a daily oral supplementation of Lycopersicon esculentum extract (similar to 2 g/kg). The number of caspase-3-labeled Purkinje neurons and granule cells present in the rats in the control and experimental groups were then counted. The neurodegenerative changes were studied using cresyl violet staining, and these changes were evaluated. In comparison with the control animals, the EMF1 group demonstrated a significant. increase in the number of caspase-3-labeled Purkinje neurons and granule cells present in the cerebellum (P<0.001). However, in comparison with the EMF1 group, the EMF2 group exhibited significantly fewer caspase-3-labeled Purkinje neurons and granule cells in the cerebellum. In the EMF1 group, the Purkinje neurons were revealed to have undergone dark neuron degenerative changes. However, the presence of dark Purkinje neurons was reduced in the EMF2 group, compared with the EMF1 group. The results indicated that apoptosis and neurodegeneration in rats exposed to EMF during pre- and postnatal periods may be reduced with Lycopersicon esculentum extract therapy.en_US
dc.language.isoengen_US
dc.publisherSPANDIDOS PUBL LTDPOB 18179, ATHENS 116 10, GREECEen_US
dc.relation.isversionof10.3892/etm.2013.1123en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosis occurs in response to a wide range of environmental stimulien_US
dc.titleEffect of Lycopersicon esculentum extract on apoptosis in the rat cerebellum, following prenatal and postnatal exposure to an electromagnetic fielden_US
dc.typearticleen_US
dc.relation.journalEXPERIMENTAL AND THERAPEUTIC MEDICINEen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0001-5463-2634en_US
dc.contributor.authorID0000-0001-5636-3300en_US
dc.contributor.authorID0000-0002-7553-5435en_US
dc.identifier.volume6en_US
dc.identifier.issue1en_US
dc.identifier.startpage52en_US
dc.identifier.endpage56en_US
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