Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3024
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dc.contributor.authorDemirhan, E. S.-
dc.contributor.authorSekeroglu, V.-
dc.contributor.authorSekeroglu, Z. Atli-
dc.date.accessioned2022-08-19T12:40:30Z-
dc.date.available2022-08-19T12:40:30Z-
dc.date.issued2014-
dc.identifier.urihttp://doi.org/10.1177/0748233712448114-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3024-
dc.description.abstractDeltamethrin (DEL) and thiacloprid (THIA) are the two commonly used synthetic insecticides applied either separately or as a mixture. The aim of this study was to assess thyroid stimulating hormone (TSH) and the serum levels of thyroid hormones exposure to these compounds in rats. The animals were orally gavaged with a single dose of DEL (15 mg/kg), THIA (112.5 mg/kg) or DEL + THIA (15 + 112.5 mg/kg) for 24 h (acute treatments) or DEL (3 mg/kg per day), THIA (22.5 mg/kg per day) or DEL + THIA (3 + 22.5 mg/kg per day) for 30 days (subacute treatments). Although all independent and combined treatments with DEL and THIA changed the levels of TSH, these alterations were not significant. Statistically significant increases in free triiodothyronine (FT3) and free thyroxine (FT4) serum hormone levels were observed in the independent treatment with THIA and the combined treatment with DEL and THIA for 30 days. The results of this study suggest that in vivo exposure to subacute treatments of commercial formulations of THI and mixture of DEL + THIA increased serum FT3 and FT4 levels in rats. Further studies are required to determine the effects of endocrine disruptors and potential health risks of these insecticides in human, especially in children because of the importance of these hormones during growth and development.en_US
dc.language.isoengen_US
dc.publisherSAGE PUBLICATIONS INC2455 TELLER RD, THOUSAND OAKS, CA 91320en_US
dc.relation.isversionof10.1177/0748233712448114en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPyrethroids, neonicotinoids, thyroid hormones, thyroid stimulating hormone, rat serumen_US
dc.titleEffects of commercial formulations of deltamethrin and/or thiacloprid on thyroid hormone levels in rat serumen_US
dc.typearticleen_US
dc.relation.journalTOXICOLOGY AND INDUSTRIAL HEALTHen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0002-3552-3819en_US
dc.contributor.authorID0000-0002-8547-6571en_US
dc.identifier.volume30en_US
dc.identifier.issue1en_US
dc.identifier.startpage40en_US
dc.identifier.endpage46en_US
Appears in Collections:Moleküler Biyoloji ve Genetik Bölümü

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