Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3001
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dc.contributor.authorAksoy, Muhammet-
dc.contributor.authorSekeroglu, Vedat-
dc.contributor.authorSekeroglu, Zulal Atli-
dc.date.accessioned2022-08-19T12:28:16Z-
dc.date.available2022-08-19T12:28:16Z-
dc.date.issued2017-
dc.identifier.urihttp://doi.org/10.1080/01480545.2016.1188305-
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/01480545.2016.1188305-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3001-
dc.description.abstractOfloxacin (OFX), a second-generation of quinolones, is a broad-spectrum flouroquinolone antibiotic used in the treatment of various bacterial infections. In this article, we aimed to investigate the cytotoxic and genotoxic potentials of OFX in cultured human peripheral lymphocytes. The cytotoxicity and genotoxicity of OFX on human peripheral blood lymphocytes were examined in vitro by sister chromatid exchange (SCE), chromosomal aberrations (CAs) and micronucleus (MN) tests. Cultures were treated with 30, 60 and 120 mu g/ml of OFX for 48 h. Dimethylsulfoxide (DMSO) was used as a solvent control. OFX decreased the mitotic index (MI) and nuclear division index (NDI) significantly, especially at higher concentrations (60 and 120 mu g/ml) compared with solvent control. OFX significantly induced CAs at all concentrations and SCEs at higher concentrations (60 and 120 mu g/ml) compared with solvent control. In conclusion, our results indicated that OFX has cytotoxic, cytostatic and genotoxic potential especially at higher concentrations on human peripheral blood lymphocyte cultures under the experimental conditions.en_US
dc.language.isoengen_US
dc.publisherTAYLOR & FRANCIS LTD, 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLANDen_US
dc.relation.isversionof10.1080/01480545.2016.1188305en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOfloxacin; cytotoxicity; chromosome aberration; micronucleus; sister chromatid exchange; human peripheral lymphocytesen_US
dc.subjectQUINOLONE ANTIBACTERIAL AGENTS; JUVENILE RABBIT CHONDROCYTES; COMET ASSAY; GENOTOXICITY; FLUOROQUINOLONES; ANTIBIOTICS; CHROMOSOMES; INDUCTION; MECHANISM; APOPTOSISen_US
dc.titleCytogenetic alterations in human lymphocyte cultures following exposure to ofloxacinen_US
dc.typearticleen_US
dc.relation.journalDRUG AND CHEMICAL TOXICOLOGYen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0002-3552-3819en_US
dc.identifier.volume40en_US
dc.identifier.issue2en_US
dc.identifier.startpage140en_US
dc.identifier.endpage145en_US
Appears in Collections:Moleküler Biyoloji ve Genetik Bölümü

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