Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2999
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dc.contributor.authorCosguner, Gamze-
dc.contributor.authorKefelioglu, Haluk-
dc.contributor.authorSekeroglu, Vedat-
dc.contributor.authorSekeroglu, Zulal Atli-
dc.contributor.authorYedier, Seval Kontas-
dc.date.accessioned2022-08-19T12:27:31Z-
dc.date.available2022-08-19T12:27:31Z-
dc.date.issued2017-
dc.identifier.urihttp://doi.org/10.1080/01480545.2016.1252920-
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/01480545.2016.1252920-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2999-
dc.description.abstractIt has been stated that some antipsychotic drugs might cause genotoxic and carcinogenic effects. Ziprasidone (ZIP) is commonly used an antipsychotic drug. However, its genotoxicity and carcinogenicity data are very limited. The cytotoxicity and genotoxicity of ZIP on human peripheral blood lymphocytes were examined in vitro by sister chromatid exchange (SCE), chromosome aberration (CA) and micronucleus (MN) tests in this study. Lymphocyte cultures were treated with 50, 75 and 100 mg/ml of ZIP in the presence and absence of a metabolic activator (S9 mix). Dimethylsulfoxide was used as a solvent control. While the cells were treated with ZIP for 24 h and 48 h in cultures without S9 mix, the cultures with S9 mix were exposed to ZIP for 3 h. ZIP and its metabolites can exert cytotoxic activities due to significant decreases in mitotic index, proliferation index and nuclear division index in the presence and absence of S9 mix. Statistically significant increases in CAs, aberrant cells and MN values in the presence and absence of S9 mix were found in cultures treated with ZIP. While ZIP significantly increased the SCE values in the absence of S9 mix at all concentrations, increased SCE values in cultures with S9 mix were not found to significantly at all concentrations tested. Our results indicated that both ZIP and its metabolites have cytotoxic, cytostatic and genotoxic potential on lymphocyte cultures under the experimental conditions. Further studies are necessary to make a possible risk assessment in patients receiving therapy with this drug.en_US
dc.language.isoengen_US
dc.publisherTAYLOR & FRANCIS LTD, 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLANDen_US
dc.relation.isversionof10.1080/01480545.2016.1252920en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIN-VITRO; DRUGS; DIFFERENTIATION; ANTIPSYCHOTICS; METABOLISM; MODELSen_US
dc.subjectZiprasidone; metabolic activation; cytotoxicity; chromosome aberration; micronucleus; sister chromatid exchange; lymphocytesen_US
dc.titleZiprasidone induces cytotoxicity and genotoxicity in human peripheral lymphocytesen_US
dc.typearticleen_US
dc.relation.journalDRUG AND CHEMICAL TOXICOLOGYen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0002-3552-3819en_US
dc.contributor.authorID0000-0002-3552-3819en_US
dc.contributor.authorID0000-0002-7421-6037en_US
dc.identifier.volume40en_US
dc.identifier.issue4en_US
dc.identifier.startpage425en_US
dc.identifier.endpage431en_US
Appears in Collections:Moleküler Biyoloji ve Genetik Bölümü

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