Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2950
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dc.contributor.authorAydin, Birsen-
dc.contributor.authorKompe, Yasemin Ozdener-
dc.contributor.authorSekeroglu, Vedat-
dc.contributor.authorSekeroglu, Zulal Atli-
dc.date.accessioned2022-08-19T11:17:08Z-
dc.date.available2022-08-19T11:17:08Z-
dc.date.issued2018-
dc.identifier.urihttp://doi.org/10.1016/j.biopha.2018.01.026-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2950-
dc.description.abstractCapsaicin (CAP) and alpha-tocopherol (TOC) have antioxidant properties. We investigated effects of CAP and TOC on mitochondrial oxidative stress and mitochondrial bioenergetics in liver of mice fed HFD. AST, ALT, glucose, homeostasis model assessment-insulin resistance index ((HOMA-IR)) and mitochondrial oxidative stress parameters increased, whereas oxidative phosphorylation (OXPHOS) enzymes, tricarboxylic acid cycle (TCA) enzymes, ATP level and mitochondrial metabolic function (MTT) decreased in mice fed a HFD compared to the fed a standard diet (NC). Treatment of HFD together with CAP (HFC group), TOC (HFT group) or TOC and CAP (HCT group) can ameliorate the examined parameters. Because co-treatment with CAP and TOC displayed a better ameliorating effect on liver redox status and mitochondrial bioenergetics functions, they can be useful to protect against HFD and oxidative stress-related in liver diseases.en_US
dc.language.isoengen_US
dc.publisherELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCEen_US
dc.relation.isversionof10.1016/j.biopha.2018.01.026en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHigh fat diet; Capsaicin; Alpha-tocopherol; Mitochondria; Liveren_US
dc.titleHepatoprotective effects of capsaicin and alpha-tocopherol on mitochondrial function in mice fed a high-fat dieten_US
dc.typearticleen_US
dc.relation.journalBIOMEDICINE & PHARMACOTHERAPYen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0002-3552-3819en_US
dc.contributor.authorID0000-0002-5541-9365en_US
dc.contributor.authorID0000-0002-8547-6571en_US
dc.identifier.volume98en_US
dc.identifier.startpage821en_US
dc.identifier.endpage825en_US
Appears in Collections:Moleküler Biyoloji ve Genetik Bölümü

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