Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2708
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dc.contributor.authorAkincioglu, Akin-
dc.contributor.authorAkincioglu, Huelya-
dc.contributor.authorAksu, Kadir-
dc.contributor.authorGoeksu, Sueleyman-
dc.contributor.authorGuelcin, Ilhami-
dc.contributor.authorTuemer, Ferhan-
dc.date.accessioned2022-08-17T07:13:44Z-
dc.date.available2022-08-17T07:13:44Z-
dc.date.issued2018-
dc.identifier.urihttp://doi.org/10.1002/ardp.201800150-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2708-
dc.description.abstractA series of sulfamides were synthesized and evaluated for their acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and carbonic anhydrase inhibition properties. The synthesis of sulfamides was achieved by the reactions of phenethylamines with N,N-dimethylsulfamoyl chloride in the presence of Et3N. The methoxylated sulfamides were converted into their phenolic derivatives with BBr3 for structure-activity relationships. The synthesized sulfamide/phenolic sulfamide derivatives were investigated as cholinesterase inhibitors and their relative role in AChE versus BChE inhibition was defined. Sulfamide/phenolic sulfamide derivatives are known as important carbonic anhydrase inhibitors; therefore, the synthesized compounds were investigated for inhibitory effects on both carbonic anhydrase isoenzymes. Additionally, we evaluated four different enzymes, which were inhibited in the low nanomolar range by these compounds. According to the present studies, for AChE, BChE, and carbonic anhydrase I and II, the ranges of results are recorded as 0.027-0.076nM, 0.075-0.327nM, 0.123-0.678nM, and 0.024-0.688nM, respectively.en_US
dc.language.isoengen_US
dc.publisherWILEY-V C H VERLAG GMBH, POSTFACH 101161, 69451 WEINHEIM, GERMANYen_US
dc.relation.isversionof10.1002/ardp.201800150en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectacetylcholinesterase; butyrylcholinesterase; carbonic anhydrase; phenethylamines; sulfamidesen_US
dc.titleSynthesis of novel sulfamides incorporating phenethylamines and determination of their inhibition profiles against some metabolic enzymesen_US
dc.typearticleen_US
dc.relation.journalARCHIV DER PHARMAZIEen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0001-5993-1668en_US
dc.identifier.volume351en_US
dc.identifier.issue9en_US
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