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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Durucasu, Inci | - |
dc.contributor.author | Eskici, Mustafa | - |
dc.contributor.author | Kabak, Yalcin | - |
dc.contributor.author | Karanfil, Abdullah | - |
dc.contributor.author | Ozer, M. Sabih | - |
dc.date.accessioned | 2022-08-17T07:09:54Z | - |
dc.date.available | 2022-08-17T07:09:54Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | http://doi.org/10.1080/00397911.2018.1489057 | - |
dc.identifier.uri | http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2698 | - |
dc.description.abstract | A practical and efficient asymmetric synthesis of (S)-dihydrokavain from known ethyl (S)-2-hydroxy-4-phenylbutanoate which is, in turn, readily available from l-malic acid as a cheap chiral pool material is described using regioselective ring-opening of the 1,2-cyclic sulfate with lithium-3,3,3-triethoxypropiolate and subsequent HgO/H2SO4-mediated lactonization as the key steps. Its opposite enantiomer (R)-dihydrokavain was also synthesized from d-malic acid using the same sequences of reactions for the purpose of optical purity determination. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | TAYLOR & FRANCIS INC, 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA | en_US |
dc.relation.isversionof | 10.1080/00397911.2018.1489057 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | 1; 2-Cyclic sulfates; dihydrokavain; lactonization; triethylorthopropiolate | en_US |
dc.title | Asymmetric synthesis of (S)-dihydrokavain from l-malic acid | en_US |
dc.type | article | en_US |
dc.relation.journal | SYNTHETIC COMMUNICATIONS | en_US |
dc.contributor.department | Ordu Üniversitesi | en_US |
dc.contributor.authorID | 0000-0003-2948-4216 | en_US |
dc.identifier.volume | 48 | en_US |
dc.identifier.issue | 18 | en_US |
dc.identifier.startpage | 2382 | en_US |
dc.identifier.endpage | 2390 | en_US |
Appears in Collections: | Kimya |
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