Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2690
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dc.contributor.authorAlpdemir, Sukran-
dc.contributor.authorBayram, Cem-
dc.contributor.authorDenkbas, Emir Baki-
dc.contributor.authorHaberal, Erdem-
dc.contributor.authorKara, Goknur-
dc.contributor.authorVural, Tayfun-
dc.date.accessioned2022-08-17T07:06:54Z-
dc.date.available2022-08-17T07:06:54Z-
dc.date.issued2020-
dc.identifier.urihttp://doi.org/10.1049/iet-nbt.2020.0139-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2690-
dc.description.abstractThis study aimed to develop sorafenib loaded magnetic microspheres for the treatment of hepatocellular carcinoma. To achieve this goal, superparamagnetic iron oxide nanoparticles (SPIONs) were synthesised and encapsulated in alginate microspheres together with an antineoplastic agent, sorafenib. In the study, firstly SPIONs were synthesised and characterised by dynamic light scattering, energy-dispersive X-ray spectroscopy, and scanning electron microscopy. Then, alginate-SPIONs microspheres were developed, and further characterised by electron spin resonance spectrometer and vibrating sample magnetometer. Besides the magnetic properties of SPIONs, alginate microspheres with SPIONs were also found to have magnetic properties. The potential use of microspheres in hyperthermia treatment was then investigated and an increase of about 4 degrees C in the environment was found out. Drug release studies and cytotoxicity tests were performed after sorafenib was encapsulated into the magnetic microspheres. According to release studies, sorafenib has been released from microspheres for 8 h. Cytotoxicity tests showed that alginate-SPION-sorafenib microspheres were highly effective against cancerous cells and promising for cancer therapy.en_US
dc.language.isoengen_US
dc.publisherINST ENGINEERING TECHNOLOGY-IET, MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLANDen_US
dc.relation.isversionof10.1049/iet-nbt.2020.0139en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDRUG-DELIVERY; IN-VITRO; NANOPARTICLES; RELEASEen_US
dc.subjectdrug delivery systems; drugs; nanofabrication; magnetic particles; iron compounds; scanning electron microscopy; hyperthermia; biomedical materials; encapsulation; nanoparticles; light scattering; nanomagnetics; cellular biophysics; toxicology; cancer; nanomedicine; superparamagnetism; nanocomposites; magnetometry; paramagnetic resonance; X-ray chemical analysis; sorafenib loaded alginate microspheres; hepatocellular carcinoma treatment; sorafenib loaded magnetic microspheres; superparamagnetic iron oxide nanoparticles; dynamic light scattering; energy-dispersive X-ray spectroscopy; scanning electron microscopy; electron spin resonance spectrometer; vibrating sample magnetometer; hyperthermia treatment; drug release; alginate-SPION-sorafenib microspheres; antineoplastic agent; cytotoxicity tests; cancerous cells; time 8; 0 hour; Fe3O4en_US
dc.titleMagnetically responsive, sorafenib loaded alginate microspheres for hepatocellular carcinoma treatmenten_US
dc.typearticleen_US
dc.relation.journalIET NANOBIOTECHNOLOGYen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0001-8717-4668en_US
dc.contributor.authorID0000-0001-9504-5532en_US
dc.contributor.authorID0000-0003-2788-550Xen_US
dc.identifier.volume14en_US
dc.identifier.issue7en_US
dc.identifier.startpage617en_US
dc.identifier.endpage622en_US
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