Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2687
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dc.contributor.authorBostanoglu, Akin-
dc.contributor.authorEvren, Ebru-
dc.contributor.authorIsik, Sevil-
dc.contributor.authorOrug, Taner-
dc.contributor.authorSaydam, Gul Sevim-
dc.contributor.authorYildiz, Baris Dogu-
dc.contributor.authorZengin, Neslihan Inci-
dc.date.accessioned2022-08-17T07:05:55Z-
dc.date.available2022-08-17T07:05:55Z-
dc.date.issued2014-
dc.identifier.urihttp://doi.org/10.5152/tjg.2014.5229-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2687-
dc.description.abstractBackground/Aims: The effects of short-bowel syndrome on liver function and liver morphology independent of parenteral nutrition have not been thoroughly investigated. Our aim was to investigate the effects of massive bowel resection on hepatocyte apoptosis and liver function in rats. Materials and Methods: A total of 37 female Sprague-Dawley rats were randomly assigned to five groups: Control (no procedure); Sham 1 [laparotomy (LT)/enterotomy (ET); evaluated on postoperative day (POD) 1]; Sham 2 (LT/ET; evaluated on POD7; Group 1 (80% bowel resection after LT/ET; POD1); and Group 2 (80% bowel resection; POD7). Blood samples were obtained for measuring aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase levels. For assessing hepatocyte apoptosis, liver tissue samples from the median lobe were obtained and used for a terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling assay. Results: Aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase levels showed statistically significant differences among the five groups. Apoptotic hepatocyte counts there were statistically significant differences among groups for counts made in 20 consecutive high-power fields. However, liver sinusoidal cell apoptosis rates among groups showed statistically significant differences for counts made in 20 consecutive highpower fields, particularly on POD7 in rats undergoing massive bowel resection. Conclusion: Parenteral nutrition is not the only factor involved in liver dysfunction after massive bowel resection. Massive bowel resection alone can cause liver abnormalities. Rats undergoing massive small intestinal resection show significant temporal increases in liver sinusoidal cell apoptosis rates.en_US
dc.language.isoengen_US
dc.publisherAVESBUYUKDERE CAD 105-9, MECIDIYEKOY, SISLI, ISTANBUL 34394, TURKEYen_US
dc.relation.isversionof10.5152/tjg.2014.5229en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectShort bowel syndrome massive bowel resection liver apoptosis liver function testsen_US
dc.titleExperimental study on the effects of massive bowel resection on liver function and hepatocyte apoptosisen_US
dc.typearticleen_US
dc.relation.journalTURKISH JOURNAL OF GASTROENTEROLOGYen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0002-3535-6977en_US
dc.identifier.volume25en_US
dc.identifier.issue6en_US
dc.identifier.startpage674en_US
dc.identifier.endpage677en_US
Appears in Collections:Cerrahi Tıp Bilimleri

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