Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2671
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dc.contributor.authorDalkara, Turgay-
dc.contributor.authorErdener, Sefik Evren-
dc.contributor.authorEylen, Alpaslan-
dc.contributor.authorGursoy-Ozdemir, Yasemin-
dc.contributor.authorKaratas, Hulya-
dc.contributor.authorLule, Sevda-
dc.contributor.authorOzveren, Mehmet Faik-
dc.contributor.authorVural, Atay-
dc.contributor.authorYildirim, Timur-
dc.date.accessioned2022-08-17T07:03:56Z-
dc.date.available2022-08-17T07:03:56Z-
dc.date.issued2015-
dc.identifier.urihttp://doi.org/10.3109/00207454.2014.979289-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2671-
dc.description.abstractUnder pathological conditions such as brain trauma, subarachnoid hemorrhage and stroke, cortical spreading depression (CSD) or peri-infarct depolarizations contribute to brain damage in animal models of neurological disorders as well as in human neurological diseases. CSD causes transient megachannel opening on the neuronal membrane, which may compromise neuronal survival under pathological conditions. Poloxamer-188 (P-188) and citicoline are neuroprotectants with membrane sealing properties. The aim of this study is to investigate the effect of P-188 and citicoline on the neuronal megachannel opening induced by CSD in the mouse brain. We have monitored megachannel opening with propidium iodide, a membrane impermeable fluorescent dye and, demonstrate that P-188 and citicoline strikingly decreased CSD-induced neuronal PI influx in cortex and hippocampal dentate gyrus. Therefore, these agents may be providing neuroprotection by blocking megachannel opening, which may be related to their membrane sealing action and warrant further investigation for treatment of traumatic brain injury and ischemic stroke.en_US
dc.language.isoengen_US
dc.publisherTAYLOR & FRANCIS LTD2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLANDen_US
dc.relation.isversionof10.3109/00207454.2014.979289en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcortical spreading depressionmegachannelsneuroprotectionpoloxamer-188citicolineen_US
dc.subjectTRANSIENT FOREBRAIN ISCHEMIATRAUMATIC BRAIN-INJURYCDP-CHOLINECLINICAL-RELEVANCEMECHANISMSNEUROPROTECTIONMIGRAINEDAMAGERATDEPOLARIZATIONen_US
dc.titlePoloxamer-188 and citicoline provide neuronal membrane integrity and protect membrane stability in cortical spreading depressionen_US
dc.typearticleen_US
dc.relation.journalINTERNATIONAL JOURNAL OF NEUROSCIENCEen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0001-7066-6471en_US
dc.contributor.authorID0000-0002-0860-8964en_US
dc.contributor.authorID0000-0003-3222-874Xen_US
dc.contributor.authorID0000-0003-3943-7819en_US
dc.contributor.authorID0000-0003-4838-6320en_US
dc.identifier.volume125en_US
dc.identifier.issue12en_US
dc.identifier.startpage941en_US
dc.identifier.endpage946en_US
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