Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2664
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dc.contributor.authorBilge, Onur-
dc.contributor.authorDoral, Mahmut Nedim-
dc.contributor.authorEsen, Hasan-
dc.contributor.authorGoncu, Recep Gani-
dc.contributor.authorGuzel, Yunus-
dc.contributor.authorKacira, Burkay K.-
dc.contributor.authorKaradag, Hakan-
dc.contributor.authorKaralezli, Nazim-
dc.contributor.authorToker, Serdar-
dc.date.accessioned2022-08-17T07:02:52Z-
dc.date.available2022-08-17T07:02:52Z-
dc.date.issued2015-
dc.identifier.urihttp://doi.org/10.1007/s00167-013-2734-2-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2664-
dc.description.abstractPlatelet-rich plasma (PRP) includes growth factors and proteins that accelerate and stimulate bone regeneration and tissue recovery. The aim of this study was to evaluate the effects of PRP on fracture healing in terms of biomechanics and histology. Seventy female rats were included in this experimental study. They were divided into three groups: Group I (no PRP, n = 30), Group II (PRP added, n = 30) and Group III (control, n = 10). The left femurs of the rats in Groups I and II were osteotomized and fixed by K-wires. Although no additional intervention was performed on Group I rats, PRP was applied to the fracture sites of Group II rats. The remaining ten rats were used as the control group of the biomechanical test (Group III). In the fourth week, nine femurs from Group I and ten femurs from Group II, and in the ninth week, nine femurs from each group were removed, and bone recovery was assessed histologically according to Modified Lane-Sandhu histological scoring criteria. Three-point bending test was applied to femurs for biomechanical evaluation in the ninth week. Histological healing was found to be significantly higher in Group II than in Group I (p < 0.05). Furthermore, biomechanical test results showed that healing quantity and bone strength were significantly better in Group II than in Group I (p < 0.05). PRP is a widely studied material in the physiology of fracture healing. The results of this study demonstrated the ameliorative biomechanical effects of PRP on fracture healing, in addition to accelerating the histological union of fractures. In the light of these results, PRP could be a viable alternative to accelerate the healing of fractures, late unions or non-unions. Prospective comparative study, Level II.en_US
dc.language.isoengen_US
dc.publisherSPRINGERONE NEW YORK PLAZA, SUITE 4600 , NEW YORK, NY 10004, UNITED STATESen_US
dc.relation.isversionof10.1007/s00167-013-2734-2en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectENDOTHELIAL-CELLSBONE-FORMATIONGROWTH-FACTORSREGENERATIONNONUNIONMODELPRGFen_US
dc.subjectPlatelet-rich plasma (PRP)PRGFFractureUnionBiomechanicsen_US
dc.titleThe biomechanical and histological effects of platelet-rich plasma on fracture healingen_US
dc.typearticleen_US
dc.relation.journalKNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPYen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0002-8555-0460en_US
dc.identifier.volume23en_US
dc.identifier.issue5en_US
dc.identifier.startpage1378en_US
dc.identifier.endpage1383en_US
Appears in Collections:Cerrahi Tıp Bilimleri

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