Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2663
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dc.contributor.authorErturk, Aliye Gediz-
dc.contributor.authorOmerustaoglu, Hilal-
dc.date.accessioned2022-08-17T07:02:39Z-
dc.date.available2022-08-17T07:02:39Z-
dc.date.issued2020-
dc.identifier.urihttp://doi.org/10.3390/molecules25040900-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2663-
dc.description.abstractIn this paper, a series of new substituted-5-pyrazolones were first synthesized, then formulated by the Vilsmeier-Haack reaction to obtain substituted-4-carbaldehyde-5-pyrazolones. In the final step, when urea was reacted with formulated pyrazolones, we found that, instead of the C=N bond in azomethine form, the compounds tautomerized to form a series of novel pyrazole-4-ylidenemethylurea structures. The structures of these compounds were elucidated by FTIR, H-1, C-13 NMR, LC-MS/MS, and elemental analysis methods. The cytotoxic and antioxidant effects of substituted 5-pyrazolones and their pyrazolone-urea derivatives were investigated in metastatic A431 and noncancerous HaCaT human keratinocytes by a mitochondrial activity test. The effects of the compounds on the migration of cancerous and noncancerous cell lines were investigated by using a cell scratch assay. The General Linear Model, Statistical Package for Social Sciences (SPSS v26) was used to determine if there was a statistically significant difference between the control and the treatment groups. Four of the nine compounds showed an antioxidant effect. All 5-pyrazolone-urea compounds showed higher toxicity (p < 0.05) in cancerous A431 cells compared to noncancerous cells at all time points. All compounds also showed a biphasic hormetic effect. Four of the nine compounds inhibited cell migration.en_US
dc.language.isoengen_US
dc.publisherMDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLANDen_US
dc.relation.isversionof10.3390/molecules25040900en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject5-pyrazolone; urea derivatives; cell proliferation; antioxidant activityen_US
dc.subjectTAUTOMERISM; PYRAZOLONES; INHIBITORS; HORMESIS; ANALOGS; SERIESen_US
dc.titleSynthesis and Cytotoxic Evaluation of Some Substituted 5-Pyrazolones and Their Urea Derivativesen_US
dc.typearticleen_US
dc.relation.journalMOLECULESen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0003-0831-7056en_US
dc.identifier.volume25en_US
dc.identifier.issue4en_US
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